关于NEC的特征,进展,管理和结果:一项回顾性队列研究
Maher Shahroor1,2, Mohamed Elkhouli3,4, Kyong-Soon Lee3,4
1Division of Neonatology, Department of Pediatrics, University of Toronto, Toronto, ON, Canada. maher.shahroor@sunnybrook.ca.
Pediatric surgery international
|November 29, 2024
概括
在早产婴儿的手术性死性肠球炎 (sNEC) 具有重大负担,往往从医学NEC (mNEC) 进展. 早期识别和干预对于改善sNEC病例的结果至关重要.
科学领域:
- 新生儿科学 新生儿科学
- 儿科手术 儿科手术
- 胃肠病学 胃肠病学
背景情况:
- 死性肠球炎 (NEC) 是早产婴儿的严重疾病,导致高发病率和死亡率.
- NEC通常从医学形式 (mNEC) 发展为外科形式 (sNEC),但也可以最初呈现为sNEC.
研究的目的:
- 为了确定NEC在早产婴儿的发病率和进展模式.
- 分析mNEC和sNEC的手术方法和结果.
- 评估sNEC的临床过程和资源利用情况.
主要方法:
- 在2010-2020年间被诊断患有NEC的早产婴儿的回顾性队列研究.
- 婴儿被分为三组:mNEC,mNEC发展为sNEC,以及 de novo sNEC.
- 收集关于临床表现,进展,治疗,手术干预和结果的数据.
主要成果:
- 在208名NEC婴儿中,52%为mNEC,32%进展为sNEC,16%呈现为sNEC.
- sNEC病例经历了更长的住院时间,增加了对呼吸系统支持,抗生素和内的需求.
- 与mNEC相比,sNEC与更高的复发性NEC,支气管肺形 (BPD) 和死亡率有关.
结论:
- 在早产婴儿的手术NEC (sNEC) 携带了大量的疾病负担.
- 了解sNEC的临床轨迹可以帮助主动管理.
- 及时干预可能有机会改善sNEC的婴儿的结果.
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