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在炎症和癌症中对人类CD8+ T细胞进行综合映射

Ziwei Xue1,2,3, Lize Wu3,4, Ruonan Tian1,3

  • 1Department of Rheumatology and Immunology of the Second Affiliated Hospital, and Centre of Biomedical Systems and Informatics of Zhejiang University, University of Edinburgh Institute, Zhejiang University School of Medicine, Hangzhou, China.

Nature methods
|November 29, 2024
PubMed
概括

这项研究介绍了scAtlasVAE,这是一个深度学习模型,用于在许多条件下分析CD8+T细胞多样性. 它揭示了对T细胞亚型及其在炎症和癌症中的作用的新见解.

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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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