鼻腔,皮肤,口腔和室内尘埃微生物及其在患有过敏性鼻炎的儿童之间的相互关系
Hao Tang1, Shuang Du1, Zhiping Niu1
1Department of Environmental Health, School of Public Health, Fudan University, NHC Key Laboratory of Health Technology Assessment (Fudan University), Shanghai, 200032, China.
BMC microbiology
|November 29, 2024
概括
这项研究揭示了过敏性鼻炎 (AR) 儿童的显著微生物特征,显示了鼻腔,皮肤和尘埃微生物群的差异. 像Staphylococcus epidermidis这样的鼻菌在AR儿童中显著影响室内灰尘和身体部位.
科学领域:
- 微生物学 微生物学
- 环境健康 环境健康
- 儿科 儿科 儿科
背景情况:
- 过敏性鼻炎 (AR) 的发病因子可能会改变微环境.
- 在AR儿童和健康对照者之间鼻子微生物群的差异是未知的.
- 在AR中,鼻腔,皮肤,口腔和室内尘埃微生物之间的相互作用需要阐明.
研究的目的:
- 为了比较细菌的特征和协会在鼻腔,皮肤,口腔和尘埃样本的儿童与AR和健康的对照.
- 为了研究微生物源的跟踪和身体部位和室内灰尘之间的转移比例.
- 识别可以区分AR儿童和健康个体的细菌物种.
主要方法:
- 病例控制研究涉及62名AR儿童和51名健康对照.
- 分析鼻腔,皮肤和口腔抹布样本,以及室内尘埃样本.
- 采用全长16S rRNA测序用于扫描片和灰尘的猎枪元基因组学,使用FEAST用于微生物源追踪.
主要成果:
- 与对照组相比,AR组中尘埃微生物的α多样性较低.
- 在AR和对照组之间,鼻腔,皮肤和尘埃微生物群的β-多样性指数存在显著差异.
- 在AR儿童的鼻腔,皮肤和尘埃样本中丰富了特定的细菌物种,包括Staphylococcus epidermidis和Staphylococcus aureus,从鼻腔中转移的比例更高.
结论:
- 该研究描述了AR儿童在环境 (尘埃) 和身体部位 (鼻腔,皮肤,口腔) 的微生物丰富.
- 鼻冠状杆菌 (Staphylococcus epidermidis) 和黄金杆菌 (Staphylococcus aureus) 在影响AR儿童的灰尘和其他身体部位方面发挥着主导作用.
- 室内灰尘,鼻腔和皮肤样本中的细菌物种在区分AR儿童和健康对照中显示出显著的潜力.
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