食品安全局关于营养药物组合中的莫纳科林含量声明是否会影响其降脂效果? 这是LopiGLIK的经验
Alessia Izzo1, Rosa Costanzo2, Lucia De Martino2
1Federico II University, Naples, Italy.
Clinical diabetes and endocrinology
|November 29, 2024
概括
红酵母大米 (RYR) 含有Monacolin-K,一种降胆固醇的化合物. 洛皮格利克有效降低LDL胆固醇,即使减少了莫纳科林-K,这表明其他成分有助于其有效性.
科学领域:
- 心血管健康 心血管健康
- 营养保健品 营养保健品
- 管理胆固醇的管理.
背景情况:
- 来自红酵母大米 (RYR) 的monacolin-K抑制了HMG-CoA减少酶以减少胆固醇.
- 由于不良影响,欧洲食品安全局 (EFSA) 建议Monacolin-K摄入量<3毫克/天.
- RYR补充剂被广泛用于管理高胆固醇血症.
研究的目的:
- 为了比较LopiGLIK®和Armolipid Plus®在降低LDL胆固醇的疗效.
- 调查莫纳科林-K剂量与其他成分在LopiGLIK®疗效中的作用.
- 评估LopiGLIK®在遵守EFSA指南后降低胆固醇的能力.
主要方法:
- 两种降胆固醇补充剂的比较研究:LopiGLIK®和Armolipid Plus®.
- 在使用补充剂的参与者中分析LDL胆固醇水平.
- 在补充剂中监测monacolin-K和berberine的含量.
主要成果:
- 与Armolipid Plus®相比,LopiGLIK®在降低LDL胆固醇方面表现出更高的疗效.
- 即使在将Monacolin-K含量降至2.99mg后,LopiGLIK®也保持了降胆固醇的作用.
- 最初在LopiGLIK®中观察到比柏林和蒙纳林-K的剂量略高.
结论:
- 洛皮格利克 (LopiGLIK®) 的增强降胆固醇效果可能归因于莫纳科林-K以外的成分,例如Morus alba.
- 这挑战了假设莫纳科林-K剂量的轻微变化是有效性的唯一驱动因素的假设.
- 需要进一步的研究来阐明RYR成分在营养保健品中的协同效应.
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