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使用酸-乳清蛋白合物增强利的水分散性和肠道向性

Xiuping Liang¹, Linlang Zhou¹, Yetong Zhang¹

¹School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.

Food research international (Ottawa, Ont.)

|November 30, 2024

概括

研究人员开发了新的乳清蛋白分离物 (WPI) - 酸 (TA) 合物,用于封装聚乙烯 (Pte). 乳糖酶诱导的合物显示出针对性肠道输送的优越性质,并增强了Pte可溶性.

科学领域:

食品科学与技术食品科学与技术
生物材料科学生物材料科学
营养药物输送系统营养药物输送系统

背景情况:

乳清蛋白分离物 (WPI) 是一种有价值的生物材料,有可能用于药物输送.
酸 (TA) 具有抗氧化特性,但在生物可用性方面面临挑战.
丁 (Pte) 是一种具有有限口服吸收的生物活性化合物.

研究的目的:

合成和表征新型乳清蛋白分离物-酸 (WPI-TA) 共价合物.
评估这些合物作为携带者,以肠道向输送二 (Pte).
评估包装Pte.的WPI-TA纳米颗粒的结构,功能和传递特性.

主要方法:

使用性处理,自由基诱导和乳酶诱导合成WPI-TA合物.
在WPI-TA纳米颗粒中封装Pte的抗溶剂沉方法.
使用SDS-PAGE进行表征,总含量,接种效率,FT-IR,颗粒大小和PDI分析.

主要成果:

通过多次分析证实了三种不同的WPI-TA共价合物的成功形成.
乳糖酶诱导的WPI-TA结合物表现出最高的酸接种效率.
在乳糖酶诱导的WPI-TA纳米颗粒中封装的Pte显示出更好的热稳定性,抗氧化活性和持续释放.
与自由Pte相比,Pte的水溶性在纳米粒子中增加了360倍以上.

结论:

乳糖酶诱导的WPI-TA结合物是封装利的有效载体.
这些WPI-TA纳米粒子为增强肠道输送和Pte.生物可用性提供了一个有希望的策略.
开发的系统显著提高了Pte的水溶性和稳定性,用于营养药物应用.

关键词:

结合在一起的配偶.拉卡斯 (Laccase) 是一个古老的城市.聚乙烯 (Pterostilbene) 是一种制剂.坦尼克酸是一种酸.乳清蛋白分离剂乳清蛋白分离剂

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