系统性审查:肠道微生物群作为结直肠癌和肥胖之间的联系
Antonio Jesús Ruiz-Malagón1,2,3, María Jesús Rodríguez-Sojo1,2, Eduardo Redondo2,4
1Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain.
概括
肠道微生物组在肥胖和结直肠癌 (CRC) 中发挥着作用. 本综述探讨了肠道微生物群的变化如何可能导致与肥胖相关的CRC发展,突出了代谢,免疫和微生物联系.
科学领域:
- 微生物组研究的研究.
- 在瘤学瘤学.
- 代谢性疾病是一种代谢性疾病.
背景情况:
- 微生物组调制为包括癌症在内的各种疾病提供了新的治疗策略.
- 肠道微生物组与结直肠癌 (CRC) 的发展,进展和治疗反应有关.
- 肥胖是CRC的主要危险因素,与肠道失调和慢性炎症有关,两者都对CRC的发病有贡献.
研究的目的:
- 系统地审查关于肥胖和CRC中的微生物组变化的证据.
- 探索微生物组变化对与肥胖相关的CRC病变的贡献.
主要方法:
- 对关于肥胖,肠道微生物群和CRC的研究进行系统审查.
- 在两个数据库中搜索临床和临床前模型.
- 包括101项研究,经由两位评论员独立提取数据后.
主要成果:
- 研究结果表明,肥胖和CRC之间存在风险关联.
- 这种关联与代谢,免疫和微生物疾病有关.
- 有证据表明,微生物组的变化有助于与肥胖相关的CRC病变.
结论:
- 微生物组的改变与肥胖和CRC有关.
- 这些微生物变化可能是与肥胖相关的CRC发展的关键因素.
- 对微生物组调节的进一步研究可能为与肥胖相关的CRC提供新的治疗途径.
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