术后口服皮质类固醇对上肢手术中的感染率的影响
Nathan Khabyeh-Hasbani1, Yufan Yan1, Joshua M Cohen1
1Montefiore Einstein, Bronx, NY, USA.
Hand (New York, N.Y.)
|November 30, 2024
概括
手术后的口服皮质类固醇在成人上肢手术中是安全的,并且不会增加手术部位感染 (SSI) 的风险. 这种6天的低剂量疗法显示了与对照组相比较的SSI率,支持其使用.
科学领域:
- 整形外科手术 整形外科手术
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
背景情况:
- 手术后的口服皮质类固醇越来越多地用于治疗手/上肢手术中的疼痛和结果.
- 人们担心感染风险增加,但缺乏证据.
- 这项研究调查了针对手术部位感染 (SSI) 的特定皮质类固醇治疗方案的安全性.
研究的目的:
- 评估6天低剂量术后口服皮质类固醇的治疗方案是否会增加成人上肢手术中手术部位感染 (SSIs) 的风险.
- 评估本治疗方案的安全性和有效性.
主要方法:
- 对813名接受干净上肢手术的成年患者的回顾性分析 (2021年11月至2023年11月).
- 在接受甲基前尼索隆6天疗程的患者和没有接受甲基前尼索隆6天疗程的患者之间,在14天和30天的SSI率的比较.
- 使用基平方和威尔科克森等级和和测试进行统计分析.
主要成果:
- 在皮质类固醇组 (4.1%) 和对照组 (3.1%) 之间,SSI率没有统计学上显著的差异.
- 分析包括196名服用类固醇的患者和617名对照患者.
- 亚组分析显示,在患有SSI的患者中,没有人口统计或并发症差异.
结论:
- 低剂量,术后6天的口服皮质类固醇使用对于成人上肢手术是安全的.
- 这种疗法不会增加手术部位感染的风险.
- 建议进行进一步的前性研究来证实这些发现.
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