相关实验视频

Updated: Jun 6, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

代谢标记器辅助的基因组预测可以改善杂交繁殖

Yang Xu¹, Wenyan Yang¹, Jie Qiu²

¹Key Laboratory of Plant Functional Genomics of the Ministry of Education/Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding/Zhongshan Biological Breeding Laboratory/Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops, College of Agriculture, Yangzhou University, Yangzhou 225009, China.

Plant communications

|November 30, 2024

概括

一种新方法,即代谢标记辅助基因组预测 (MM_GP),通过使用代谢标记来提高预测准确度,改善了作物杂交育种. 这种方法提高了玉米和大米的预测能力,提供了一种更有效的方式来选择优秀的杂交品种.

科学领域:

植物育种植物育种
基因组学就是基因组学.
代谢学代谢学代谢学

背景情况:

杂交育种对于提高玉米和大米等作物的作物产量至关重要.
从众多交叉中选择最佳的混合组合是一个重大挑战.
基因组选择 (GS) 提供了一个强大的工具,但其实际应用依赖于准确的预测.

研究的目的:

开发和评估一种新的方法,即代谢标记辅助基因组预测 (MM_GP),以提高基因组混合预测的准确性.
将通过代谢全组关联研究 (MWAS) 确定的代谢标记物整合到GS模型中.
评估MM_GP在玉米和大米杂交种群中的疗效.

主要方法:

进行了全代谢相关性研究 (MWAS),以确定与表型相关的显著代谢标志物.
开发了一个新的MM_GP模型,将这些代谢标记物纳入GS框架.
使用玉米和大米杂交数据,MM_GP的性能与传统的基因组预测 (GP) 和集成的基因组-代谢预测 (M_GP) 相比较.

主要成果:

MM_GP在玉米 (增长4.6%) 和大米 (增长13.6%) 的所有测试特征的预测能力方面始终超过了GP.
在大多数特征上,MM_GP实现了与M_GP相似的或比M_GP更好的预测能力.
在玉米中,仅整合六个关键代谢标志物,平均预测能力比GP提高5.0%,比M_GP提高3.1%.

结论:

MM_GP代表了基因组杂交育种的重大进步,提高了预测准确性和效率.
代谢标记物的整合为优化杂交选择提供了一个有价值的策略.
这种方法有望通过高吞吐量代谢学和预测模型的进步,彻底改变作物育种.

关键词:

基因组预测基因组预测混合动力混合动力混合动力混合动力代谢标志物的代谢标志物全代谢组相关性研究.预测能力预测能力预测能力

更多相关视频

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization

Published on: July 27, 2021

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics

Published on: June 17, 2012

相关概念视频

Hybrid Zones

Hybrid Zones

Hybrid zones are narrow regions where two closely related species interact, mate, and produce hybrids. Relative to either parent species, hybrids may possess distinct phenotypic or genetic differences that impact their survival and reproductive success. The genetic variances introduced by hybridization influence species diversity and speciation processes within the hybrid zone.

Plant Breeding and Biotechnology

Plant Breeding and Biotechnology

Crop cultivation has a long history in human civilization, with records showing the cultivation of cereal plants beginning at around 8000 BC. This early plant breeding was developed primarily to provide a steady supply of food.

Trihybrid Crosses

Trihybrid Crosses

Trihybrid Crosses
Some of Mendel’s crosses examined three pairs of contrasting characteristics. Such a cross is called a trihybrid cross. A trihybrid cross is a combination of three individual monohybrid crosses. For example, plant height (tall vs. short), seed shape (round vs. wrinkled), and seed color (yellow vs. green).
The F1 generation plants of a trihybrid cross are heterozygous for all three traits and produce eight gametes. Upon self-fertilization, these gametes have an equal...