患有急性视网膜动脉封闭的患者的早期再注血:一个多中心前性研究
Youssef Abdelmassih1, Martine Mauget-Faÿsse1, Pierre Seners2
1Department of Ophthalmology, Rothschild Foundation Hospital, Paris, France.
概括
中央视网膜动脉封闭 (CRAO) 的早期再输 (ER) 在近50%的患者中发生. 实现ER显著改善视力敏度和生活质量,这表明增强ER的疗法可以改善结果.
科学领域:
- 眼科医生 眼科 眼科
- 血管医学 血管医学
- 视网膜疾病 视网膜疾病
背景情况:
- 中央视网膜动脉封闭 (CRAO) 往往导致视觉结果差.
- 早期再输血 (ER) 与CRAO的临床结果之间的关系尚不清楚.
- 分支视网膜动脉封闭 (BRAO) 也可能导致显著的视力丧失.
研究的目的:
- 评估急性中央视网膜动脉封闭 (CRAO) 或分支视网膜动脉封闭 (BRAO) 中早期再输 (ER) 的发生率.
- 评估ER与临床结果之间的关联,包括视力敏度,视野和生活质量.
- 研究完整与部分ER对患者结局的影响.
主要方法:
- 未来的观察性多中心研究,包括患有急性CRAO或涉及斑点的BRAO的患者,在24小时内呈现.
- 早期转血 (ER) 评估在24小时内使用氨酸绿色血管学 (ICGA).
- 主要结局:在1个月的随访期间,最佳校正视力敏度 (BCVA).
主要成果:
- 在49%的患者 (34/70) 中发现了早期再输血 (ER).
- 患有ER的患者在1个月的BCVA (1.3 logMAR与1.7 logMAR) 中显著改善,视野和生活质量得到改善.
- 完整的再注射显示出更大的视觉益处的趋势 (p < 0.001).
结论:
- 早期再输血 (ER) 发生在近50%的CRAO或BRAO患者中.
- ER与视觉效果和生活质量的改善密切相关.
- 旨在增加CRAO中的ER的治疗策略有望改善临床结果.
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