在第一发精神病后的第一年开始服用抗精神病药物:一个基于人口的研究
I Odsbu1, A Hamina2, V Hjellvik1
1Department of Chronic Diseases, The Norwegian Institute of Public Health, Oslo, Norway.
Acta psychiatrica Scandinavica
|November 30, 2024
概括
超过一半的第一发精神病患者在一年内开始接受抗精神病治疗,口服药物最常见. 社会经济和临床因素影响了启动,表明潜在的不遵守或疾病严重程度问题.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 抗精神病药物治疗建议患者经历精神病的第一个发作.
- 了解现实世界抗精神病药物使用模式对于完善临床实践至关重要.
- 这项研究调查了第一发精神病患者的抗精神病启动和相关因素.
研究的目的:
- 为了描述抗精神病药物启动的模式,在第一发精神病诊断后的一年内.
- 为了确定与这群人群中抗精神病药物启动相关的社会经济和临床因素.
主要方法:
- 一项以人口为基础的队列研究利用了挪威的全国健康和人口登记册.
- 包括8052名年龄在16-45岁的个人,在2011-2019年间被诊断患有第一发精神病 (ICD-10 F20,F22-F29).
- 抗精神病药物的启动是通过在诊断后365天内发放记录来定义的;修改后的Poisson回归分析了相关因素.
主要成果:
- 54.8%的患者开始使用抗精神病药物,开始使用率从45.5% (2012) 增加到62.1% (2019).
- 口服 olanzapine,quetiapine 和 aripiprazole 是最常见的启动剂; 长效注射药和 clozapine 很少使用.
- 较低的年龄,高等教育,就业,住院,晚期诊断和伴随性情绪/焦虑障碍与启动有关.
结论:
- 抗精神病药物处方模式通常与临床指南保持一致.
- 观察到的社会经济和临床发病差异可能与原发性不合规或疾病严重程度有关.
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