相关实验视频

Updated: Jun 6, 2025

Non-Aqueous Isolation and Enrichment of Glandular Capitate Stalked and Sessile Trichomes from Cannabis sativa

Non-Aqueous Isolation and Enrichment of Glandular Capitate Stalked and Sessile Trichomes from Cannabis sativa

Published on: May 12, 2023

从Hypholoma capnoides 81919中分离出来的四种新型卡里奥菲伦基基基

Yu-Ting Wang^1,2, Yuan Dong³, Fang Wang³

¹Beijing Institute of Pharmacology and Toxicology, Beijing, China.

Chemistry & biodiversity

|November 30, 2024

概括

研究人员从Hypholoma capnoides中分离出了四种新的卡里奥菲伦基. 这些化合物,以及已知的德里曼基基,显示出最小的细胞毒性和没有抗菌活性.

科学领域:

自然产品化学自然产品化学
菌类学菌类学是指菌类学.
有机化学有机化学

背景情况:

Hypholoma capnoides是一种生物活性天然产品的来源.
甲类是有机化合物的多样化类别,具有各种生物活动.

研究的目的:

从Hypholoma capnoides中分离和描述新型的类类动物.
评估孤立化合物的细胞毒性和抗菌活性.

主要方法:

发酵Hypholoma capnoides的发酵. 这是一个很好的方法.
使用色谱技术进行隔离和净化.
通过综合光谱数据分析 (NMR,ORD) 阐明结构.
对BV2,MCF-7和A549细胞系进行细胞毒性测定.
针对金黄色葡萄球菌和大肠杆菌的抗菌分析.

主要成果:

发现了四种新型的卡里奥菲伦基基 (1-4) 具有罕见的三环或两环骨.
一个已知的德里曼塞斯基特化物 (5) 也被分离出来.
化合物1-5对测试的癌症和微质细胞系表现出非常弱的细胞毒性.
没有观察到任何化合物对黄金葡萄球菌或大肠杆菌的抗菌活性.

结论:

希波罗马卡普诺伊德 (Hypholoma capnoides) 的发酵产生了具有独特结构特征的新型类类.
隔离的塞斯基特类物质具有有限的细胞毒性和抗菌性.
进一步的研究可能会探索结构修改以增强生物活性.

关键词:

这种植物是Hypholoma capnoides.它具有抗菌活性,具有抗菌活性.基底基因基因基因基因基因基因细胞毒性细胞毒性六方烯类物质 (sesquiterpenoids) 是一种有机物质.

更多相关视频

Isolating Free Carbenes, their Mixed Dimers and Organic Radicals

Isolating Free Carbenes, their Mixed Dimers and Organic Radicals

Published on: April 19, 2019

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units

Published on: September 18, 2016

相关概念视频

Aromatic Hydrocarbon Cations: Structural Overview

Aromatic Hydrocarbon Cations: Structural Overview

Cycloheptatriene is a neutral monocyclic unsaturated hydrocarbon that consists of an odd number of carbon atoms and an intervening sp3 carbon in the ring. The three double bonds in the ring correspond to 6 π electrons, which is a Huckel number, and therefore satisfies the criteria of 4n + 2 π electrons. However, the intervening sp3 carbon disrupts the continuous overlap of p orbitals. As a result, cycloheptatriene is not aromatic.
Removing one hydrogen from the intervening CH2 group...

Aldehydes and Ketones with HCN: Cyanohydrin Formation Overview

Aldehydes and Ketones with HCN: Cyanohydrin Formation Overview

Cyanohydrins are compounds that contain –CN and –OH groups on the same carbon atom. They are formed by the nucleophilic addition of the cyanide ions to the carbonyl group. Cyanide ions are highly basic and nucleophilic and can be generated from HCN under aqueous conditions. However, since HCN is a weak acid, the number of cyanide ions generated is very small. Hence, a small amount of base or KCN/NaCN is added to HCN to increase the concentration of the cyanide ions in the reaction...