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,和暴露与慢性病之间的关联:来自四种实际统计模型的证据
Jiongli Huang1,2, Jingying Mao1, Huilin Liu1
1Scientific Research Academy of Guangxi Environmental Protection, Nanning, 530022, China.
Environmental geochemistry and health
|November 30, 2024
概括
对 (As), (Pb) 和 (Cd) 的暴露会增加慢性病 (CKD) 的风险. 对这些金属的联合暴露与更高的CKD风险有关,其中起了主导作用.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 环境污染物如 (As), (Pb) 和 (Cd) 是慢性病 (CKD) 的潜在危险因素.
- 这些金属化物对CKD发展的独立和联合影响仍然不完全理解.
研究的目的:
- 调查环境中暴露于As,Pb和Cd对患CKD风险的独立和综合影响.
- 阐明每种金属 (?? 化物) 和它们的混合物在CKD病变发生过程中的作用.
主要方法:
- 这是一项涉及1398个人的横截面研究.
- 测量尿 (UA),尿 (UCd) 和血 (BPb) 的水平.
- 利用通用线性模型 (GLM),受限立方线 (RCS) 模型,加权量子和回归 (WQS) 和贝叶斯内核机回归 (BKMR) 来评估暴露-CKD关联.
主要成果:
- 与对照人群相比,慢性结核病患者观察到UA,UCd,BPb和肌素调整后UCd (UCdCr) 的升高.
- 较高的UA,UCd和UCdCr四分位数与CKD风险增加显著相关 (ORs从1.79到2.84).
- WQS和BKMR模型表明,与As,Pb和Cd混合物的同时暴露与CKD风险增加有关,其中As是主要的贡献者,以及Cd和Pb之间的潜在协同作用.
结论:
- 对和的单次暴露与慢性病风险增加有关.
- ,和的联合暴露显著增加了CKD风险,在观察到的关联中起到了主导作用.
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