通过高速悬浮火焰喷射获得的富含铜的酸涂层. 各种气体参数对生物相容性的影响
Long-Quan R V Le1, M Carolina Lanzino2, Matthias Blum2
1G.E.R.N. Center of Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106, Freiburg, Germany.
Journal of materials science. Materials in medicine
|November 30, 2024
概括
这项研究优化了使用高速悬浮火焰喷雾 (HVSFS) 进行骨植入物的酸 (HAp) 涂层. 添加铜 (Cu) 增强了抗菌性质,同时保持生物相容性,这表明了更安全,更有效的植入物的最佳参数.
科学领域:
- 生物材料科学 生物材料科学
- 整形外科工程 整形外科工程
- 纳米技术 纳米技术
背景情况:
- 酸 (HAp) 涂层可以增强骨植入物的整合,但易受感染.
- 周围假肢关节感染仍然是一个重大的临床挑战.
- 开发抗感染的HAp涂层对于改善植入物寿命和患者的治疗结果至关重要.
研究的目的:
- 为了研究高速度悬浮火焰喷雾 (HVSFS) 过程中气体参数对HAp涂层性能的影响.
- 为了评估铜 (Cu) 合HAp涂层的抗菌功效和生物相容性.
- 为了确定最佳的HVSFS参数和Cu含量,以提高骨植入物性能.
主要方法:
- 使用控制气体参数的HVSFS制造HAp涂层.
- 铜 (Cu) 通过外部注射以不同度 (0-1.5重量%) 加入到HAp涂层中.
- 评估了涂层特性 (多孔性,硬度),抗菌活性 (对大肠杆菌和金黄色杆菌的空气传播试验) 和细胞毒性 (MG63细胞系).
主要成果:
- 气体参数显著影响了HAp涂层的孔隙性和硬度.
- 的融入和释放速度因气体参数而异.
- 在所有Cu-doped涂层中观察到大肠杆菌殖民地形成单位 (CFU) 的显著减少.
- 1.5重量%的Cu添加减少了S. aureus CFU,在120小时内释放14.3 mg/L的细胞毒性值.
结论:
- 中等气体参数与1重量%的Cu添加相结合,为HAp涂料提供了抗菌功效和生物相容性之间的有希望的平衡.
- HVSFS是一种可行的方法,用于生产具有可调节性质的功能化HAp涂层.
- 优化的Cu-doped HAp涂层有潜力减少植入物相关的感染.
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