微量元素与重元素的模式识别在患有膜性脏病的患者中
Xiaochang Xu1,2, Jing Xu3, Weiji Xie3
1The Division of Nephrology, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510000, People's Republic of China.
Biological trace element research
|November 30, 2024
概括
血液和尿液中的微量元素含量在膜性脏病患者和健康个体之间有所不同. 像和这样的特定元素显示出显著的差异,有助于疾病模式的识别.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 环境健康 环境健康
- 分析化学 分析化学
背景情况:
- 膜性病是成年人性综合征的主要原因之一.
- 微量元素和重金属与各种生理和病理过程有关.
- 了解元素概况可以提供有关疾病机制和生物标志物的见解.
研究的目的:
- 调查微量和重元素在膜性病的模式识别中的作用.
- 量化膜性病患者,IgA病患者和健康对照患者血液和尿液中的特定元素.
- 识别可能作为膜性病的生物标志物的元素差异.
主要方法:
- 17个元素 (V, Cr, Mn, Co, Ni, Cu, Zn, Ga, As, Se, Sr, Cd, Cs, Ba, Pb, Hg) 的量化使用感应合等离子体质谱法.
- 分析了来自14名膜性病患者,14名IgA病患者和13名健康对照者的血液和尿液样本.
- 主要组件分析 (PCA) 和正交部分最小平方差分分析 (OPLS-DA) 的应用,用于数据解释.
主要成果:
- 与对照人群相比,膜性病患者的血中Cr,Co,Ni,Cu,Zn,Ga,As,Cd,Ba水平显著降低,Se,Pb,Hg水平更高.
- 尿液中的Co,Ni,Cu,Zn水平较低,而Hg在膜性病患者和对照患者中较高.
- 当将膜性病与IgA病进行比较时,观察到不同的元素概况,血液V,Cr,Co,Cu,As,Sr,Cd,Ba和尿液Sr,Ba的显著差异;Pb和Hg在膜性病中较高.
- PCA和OPLS-DA确定了Co,Zn,Hg,Ba (血液) 和Co,Ni (尿液) 作为膜性病与对照之间的关键区分因素.
- Sr (血液) 和Pb,Sr (尿) 是区分膜性病与IgA病的重要贡献者.
结论:
- 基本分析显示,膜性脏病患者的微量和重金属概况存在显著差异.
- 特定的元素,如,,,和显示潜在的生物标志物,以区分膜性病与健康对照和IgA病.
- 这些发现支持了元素失调在膜性病变的发病过程中的作用,并强调了它们在诊断模式识别中的实用性.
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