在创伤后应激障碍,代谢综合征和心理弹性中奖励功能
Leigh Luella van den Heuvel1, Laila Asmal1, Stefan du Plessis1
1Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Francie van Zijl Drive, Tygerberg 7505, Cape Town, South Africa; Genomics of Brain Disorders, Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa.
Psychiatry research. Neuroimaging
|November 30, 2024
概括
创伤后应激障碍 (PTSD) 和代谢综合征 (MetS) 可能涉及奖励系统功能障碍. 心理性通过调节奖励系统活动来影响PTSD的结果,这表明了潜在的干预目标.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 奖励系统功能障碍与代谢综合征 (MetS) 和创伤后应激障碍 (PTSD) 的并发症有关.
- 心理性可能通过影响奖励系统来影响PTSD的结果.
研究的目的:
- 研究奖励系统的功能与PTSD,MetS和心理性有关.
- 在功能磁共振成像 (fMRI) 期间使用货币激励延迟任务.
主要方法:
- 病例对照研究比较PTSD (n=88) 和受创伤暴露的对照 (TEC,n=85).
- 使用fMRI评估腹腔条纹体 (VS) 和轨道前皮层 (OFC) 的激活.
- 对抑郁症严重程度,童年创伤和创伤负荷进行控制.
主要成果:
- 最初,PTSD和MetS组之间的VS和OFC激活没有显著差异.
- 在控制抑郁症时,PTSD病例显示较低的VS激活和较大的OFC激活增加.
- 心理性与减少的VS激活和增加的OFC激活相关.
结论:
- 抑郁症和心理性影响了PTSD中奖励系统的功能.
- 结果表明,针对PTSD治疗的积极价值系统的干预措施.
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