德国抗发作药物短缺:这个问题有多大?
Josephine Steidl1, Sabine Krebs2, Karel Kostev3
1Department of Neurology, Epilepsy Center Erlangen, Full Member of ERN EpiCARE, University Hospital Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany.
Epilepsy & behavior : E&B
|November 30, 2024
概括
药物短缺影响了2023年7月德国11%至15%的抗发作药物 (ASM) 配方. 一般的ASM和大约三分之二的制造商更频繁地经历了这些短缺.
科学领域:
- 药理学和制药科学 药理学和制药科学
- 医疗保健服务研究 医疗服务研究
- 药物供应链管理 药物供应链管理
背景情况:
- 药物短缺对全球患者护理和医疗保健系统构成重大挑战.
- 抗发作药物 (ASM) 对于治疗和其他神经疾病至关重要.
- 了解ASM短缺的流行和模式对于积极的缓解策略至关重要.
研究的目的:
- 确定德国抗发作药物 (ASM) 药物短缺和中断的频率.
- 分析配方,ASM和制造商层面的短缺问题.
- 确定受可用性问题影响最大的特定ASM和制造商.
主要方法:
- 德国制药批发商数据库的回顾性分析 (2023年7月).
- 包括来自两个主要批发商的数据,占德国市场约45%.
- 专注于确定ASM配方和制造商的药物短缺 (未满足需求) 和干扰 (完全未满足需求).
主要成果:
- 10.8%至15%的ASM配方在两个主要批发商中经历了药物短缺.
- 显著的制造商参与,其中63.2%至66.1%报告短缺.
- 与品牌药物 (16.7%) 相比,通用ASM受到的影响不成比例 (83.3%).
- 普雷加巴林, levetiracetam 和 carbamazepine 是最经常受到影响的化合物.
结论:
- 在2023年7月,在德国,大量的ASM配方 (11%-15%) 面临着药物短缺问题.
- 通用抗发作药物比他们的品牌同行更容易受到短缺的影响.
- 一个很高的百分比的制造商报告药物短缺,表明系统性供应链问题.
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