perfluoroalkyl 物质暴露和不良妊娠结果之间的潜在因果关系:双向的双样本孟德尔随机化研究
Yuanyuan Zhou1, Yujia Luo2, Yijie Lu3
1Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Ecotoxicology and environmental safety
|November 30, 2024
概括
孕产妇暴露在per-和多基基物质 (PFAS) 中可能会因果性地增加妊娠不良结果 (APO) 的风险. 特定的PFAS如PFOA和PFOS与诸如胎盘突发症和孕前等疾病有关.
科学领域:
- 环境健康 环境健康
- 生殖流行病学 生殖流行病学
- 遗传流行病学遗传流行病学
背景情况:
- 孕产妇暴露在per-和多基基物质 (PFAS) 中与不良妊娠结果 (APO) 有关.
- 对于PFASs-APOs链接的遗传因果关系尚不清楚.
- 门德尔随机化 (MR) 可以调查暴露和结果之间的因果推理.
研究的目的:
- 通过双向两样 MR 方法,研究基因预测的孕产妇 PFAS 暴露和 APO 风险之间的潜在因果关系.
- 探索APO与PFAS暴露的潜在反向因果关系.
主要方法:
- 使用了两个样本的门德尔随机化设计.
- 采用了PFAS的GWAS数据和APO的FinnGen联盟数据.
- 逆方差加权是主要估计方法,使用MR-Egger,MR-PRESSO和Cochran的Q测试进行灵敏度分析和异质性.
主要成果:
- 暴露在 perfluorooctanoic 酸 (PFOA) 中因果关系与胎盘突发 (OR=1.498) 和短妊娠/低出生体重 (OR=1.720) 的风险增加有关.
- 暴露于 perfluorooctanesulfonic 酸 (PFOS) 与孕前/孕 (OR=1.128) 和孕期高血压 (OR=1.076) 的风险增加有关,但导致膜早破的风险降低 (OR=0.916).
- 敏感性分析证实了研究结果的可靠性,反向MR表明没有明显的反向因果关系.
结论:
- MR 分析提供了特定 PFAS (PFOA,PFOS) 在某些不良妊娠结果的发展中可能起因作用的证据.
- 这些发现支持了在怀孕期间减轻PFAS暴露的策略的需要.
- 这项研究为调查环境污染物暴露和人类疾病因果关系提供了一个框架.
关键词:
负面的怀孕结果.因果关系是因果关系.门德尔的随机化和多醇基物质是多和多的.perfluorooctanesulfonic 酸是一种多酸的硫酸.perfluorooctanoic 酸 的含量是多少更多相关视频
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