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基于益生菌碳水化合物的有针对性输送方面的进展:克服生物活性成分的胃肠道挑战

Yunzhen Zhang¹, Jian He², Hong Zeng¹

¹School of Food and Health, Beijing Technology and Business University, Haidian, 100048, Beijing, PR China.

|November 30, 2024

概括

益生菌碳水化合物矩阵增强了天然生物活性成分的口服生物可用性. 这些有针对性的输送系统改善了胃肠道屏障的穿越和释放,有利于食品和健康应用.

科学领域:

营养科学营养科学
生物材料科学生物材料科学
药理学药理学是指药理学的学科.

背景情况:

天然生物活性成分往往表现为口服生物可用性较差,限制了它们的治疗和功能应用.
有效的输送系统对于克服胃肠道障碍和实现这些化合物的向释放至关重要.
益生菌碳水化合物为开发先进的输送系统提供了一个有希望的矩阵.

研究的目的:

综合审查使用益生菌碳水化合物矩阵的有针对性的输送系统.
探索这些系统的结构,释放机制和应用.
为开发和应用基于益生菌碳水化合物的传递系统在食品和健康领域提供见解.

主要方法:

对生物活性成分的向输送系统的文献审查.
封装方法的分析,包括纳米水凝,纳米颗粒,纳米乳液,微/纳米囊和纳米纤维.
检查由结肠环境 (pH,粘液,微生物群,酶) 影响的释放机制.

主要成果:

益生菌碳水化合物矩阵可以将生物活性成分封装成各种纳米和微结构,以控制释放.
通过与特定生理因素的相互作用来实现对结肠的向输送.
由结肠微生物群发酵的前生物碳水化合物产生有益的后生物.

结论:

基于益生菌碳水化合物的向输送系统提供了一种可行的策略,以改善天然生物活性成分的口服生物可用性.
这些系统有助于控制释放和有针对性的输送到结肠,提高食品和卫生部门的有效性.
益生菌碳水化合物的双重功能 (输送矩阵和微生物群调节器) 对未来的发展具有重大潜力.

关键词:

生物活性成分生物活性成分生物可用性生物可用性有控制释放的释放.益生菌碳水化合物益生菌碳水化合物有针对性的交付系统.

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