双甲因累积细胞的功能障碍而影响卵细胞成熟
Yajie Chen1, Shuang Zhang1, Yifan Sun1
1Guangdong Province Key Laboratory, Southern China Institute of Large Animal Models for Biomedicine, School of Pharmacy and Food Engineering, Wuyi University, Jiangmen, China.
Theriogenology
|November 30, 2024
概括
双甲 (BPA) 暴露会破坏累积细胞功能,从而损害卵细胞成熟和减少胚胎发育,从而损害生殖健康. 这种内分泌干扰物影响关键的细胞过程,影响生育结果.
科学领域:
- 生殖生物学 生殖生物学
- 环境毒理学环境毒理学
- 细胞生物学 细胞生物学
背景情况:
- 双甲 (BPA) 是一种普遍存在的内分泌干扰物,已知对生殖系统有不良影响.
- 积分细胞在支持卵细胞成熟和发育方面发挥着至关重要的作用.
- 乙A对累积细胞功能和随后的卵细胞质量的影响需要进一步研究.
研究的目的:
- 为了研究双甲 (BPA) 暴露对累积细胞功能的影响.
- 确定BPA暴露如何影响卵细胞成熟和随后的胚胎发育.
- 为了阐明BPA的毒性背后的细胞机制,在累积-卵细胞复合体的背景下.
主要方法:
- 在生殖囊泡阶段的猪卵细胞被BPA暴露了44小时.
- 评估累积细胞功能,包括介质分裂,内质网膜应激和类固醇合成.
- 通过测量活性氧物种,线粒体分布,自和亡来评估卵细胞质量.
- 确定了暴露于BPA的卵细胞在体外成熟和伴生代激活后的胚胎细胞阶段的发育潜力.
主要成果:
- 暴露于BPA诱导了累积细胞功能障碍,其特征是受抑制的介质分裂,内质网膜应激和破坏的类固醇合成.
- 暴露于BPA的卵细胞表现出活性氧物种增加和线粒体分布异常.
- 暴露于BPA的群体的成熟卵细胞显著减少了发展到胚芽细胞阶段.
- 暴露于BPA导致成熟卵细胞的自和亡增加.
结论:
- 累积卵细胞复合体在生殖囊泡阶段对双甲 (BPA) 暴露非常敏感.
- 乙A对积分细胞的毒性影响显著损害了卵细胞的成熟和胚胎的 partenogenetic 发育.
- 由于在支持卵细胞的环境中破坏关键细胞功能,BPA对生殖潜力构成相当大的风险.
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