相关实验视频

Updated: Jun 6, 2025

Monitoring Endoplasmic Reticulum Calcium Homeostasis Using a Gaussia Luciferase SERCaMP
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Monitoring Endoplasmic Reticulum Calcium Homeostasis Using a Gaussia Luciferase SERCaMP

Published on: September 6, 2015

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在清除过程中,与质网膜压力相关的缺陷会促进神经元功能障碍,而这种功能障碍是由SERCA2基因增强阻止的

Yukihiro Shiga1, Aline Giselle Rangel Olguin2, Sana El Hajji1

  • 1Department of Neuroscience, University of Montreal, PO box 6128, Station Centre-ville, Montreal, Quebec H3C 3J7, Canada; Neuroscience Division, Centre de recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), 900 Saint Denis Street, Montreal, Quebec H2X 0A9, Canada.

Cell reports. Medicine
|November 30, 2024
PubMed
概括

通过增强SERCA2功能来恢复视网膜神经元中的 (Ca2+) 调节,可以逆转视力丧失和神经退行. 这种方法减轻了内质网膜的压力,并恢复了神经电路平衡,以改善视觉行为.

关键词:
的恒常性是的恒常性.细胞内膜网膜的压力应激基因治疗的基因疗法玻璃眼 glaucoma 玻璃眼 玻璃眼 玻璃眼 玻璃眼在活体中成像成像神经退行症的神经退行症器官的压力压力是有机体.视网膜的质细胞细胞.石内细胞网膜 (ER) -ATPase2 (SERCA2 / ATP2A2) 是一个创伤性视神经病变是一种创伤性视神经病变.

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Live Cell Calcium Imaging Combined with siRNA Mediated Gene Silencing Identifies Ca2+ Leak Channels in the ER Membrane and their Regulatory Mechanisms13:40

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相关概念视频

Role of ER in the Secretory Pathway01:17

Role of ER in the Secretory Pathway

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ER Retrieval Pathway

In the secretory pathway, vesicles transport proteins from one cellular compartment to another in forward transport to deliver the protein to its correct location. Occasionally, misfolded proteins and incorrect proteins escape their original compartments, and a retrieval pathway is used to return the escaped proteins to their original compartment.
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Export of Misfolded Proteins out of the ER

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Post-translational Translocation of Proteins to the RER01:27

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A sizable fraction of proteins destined for ER are first synthesized in the cell cytosol and then transported across the ER membrane–a process called post-translational translocation. Similar to cotranslationally translocated proteins, these proteins also use the Sec translocon complex to enter the ER lumen.
Targeting proteins to the ER
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The Endoplasmic Reticulum01:43

The Endoplasmic Reticulum

The endoplasmic reticulum or ER makes up for more than half of the membranes in a cell and accounts for 10% of total cell volume. It is also the primary protein and lipid synthesis factory for most cell organelles, such as the Golgi apparatus, lysosomes, secretory vesicles, and the plasma membrane. Despite being the most extensive and functionally complex subcellular organelle, ER was the last to be discovered. After years of deliberation, Keith Porter and George Palade in the year 1954,...
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