相关实验视频

Updated: Jun 6, 2025

Formation of Dispersible Taohong Siwu Tablets

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

通过液床颗粒化药物纳米悬浮来制备具有个性化溶解配置的小盘

Elizaveta Mutylo¹, Ondřej Navrátil¹, Adam Waněk¹

¹Department of Chemical Engineering, University of Chemistry and Technology Prague, Technická 5, Prague 6, 16628, Czech Republic; Zentiva k.s., U Kabelovny 130, Prague 10, 10237, Czech Republic.

International journal of pharmaceutics

|November 30, 2024

概括

这项研究开发了一种使用活性药物成分 (API) 纳米悬浮来创建固体剂型的新型流体床颗粒化方法. 这种技术使可调节的药物释放用于精密医学应用.

科学领域:

制药科学制药科学
药物运输药物运输药物运输
材料科学材料科学材料科学

背景情况:

可溶性较差的活性药物成分 (API) 需要增强溶解,以提高生物可用性.
纳米悬浮在改善API溶解方面是有效的,但在固体剂型制造方面存在挑战.
在转化为固体形式期间,维持纳米悬浮的再分散性至关重要.

研究的目的:

开发一种方法,从API纳米悬浮中产生固体剂型,而不会影响再分散性.
为了研究使用API纳米悬浮作为粘合剂的流体床颗粒的使用.
为了在多单位剂量形式 (MUDF) 囊中实现可调节的药物释放配置文件.

主要方法:

一个API纳米悬浮被准备使用湿媒介削.
在纳米悬浮粘合剂中加入了聚合物辅料 (基甲基纤维素E5,聚烯利 K30).
流体床颗粒剂被用于使用纳米悬浮粘合剂颗粒化微晶纤维素或Pearlitol CR-H基板.
颗粒被加工成MUDF囊配方的微粒.

主要成果:

成功地获得了具有系统变化的溶解性质的颗粒.
开发的方法允许形成MUDF囊.
可调节的药物释放概况是通过结合微型药物来实现的.

结论:

使用API纳米悬浮结合剂的流体床颗粒化为制造固体剂型提供了一种可行的方法.
这种方法保留了纳米悬浮的特性,并使药物释放得到控制.
该方法支持精密药物的合理设计和制造.

关键词:

解散解散解散是一个过程.流体床颗粒化过程中的流体床.迷你小子迷你小子这是一种纳米悬浮.精准医学是一门精准的医学.

更多相关视频

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

相关概念视频

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...

Factors Influencing Drug Absorption: Drug Dissolution

Factors Influencing Drug Absorption: Drug Dissolution

The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...

Theories of Dissolution: Diffusion Layer Model

Theories of Dissolution: Diffusion Layer Model

Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model

Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the...