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相关概念视频

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

780
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
780

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揭示片结构变化:微计算机断层分析水性涂层效应的微计算机断层分析.

Davide D'Angelo1, Eride Quarta1, Gianluca Bazzoli1

  • 1Department of Food and Drug Sciences, University of Parma, Parco Area delle Scienze 27/A, Parma 43124, Italy.

International journal of pharmaceutics
|November 30, 2024
PubMed
概括

水性平板电脑涂层可能会导致由于水相互作用而增加多孔性和裂. 平板电脑组件的机械性能显著影响这些结构变化,影响最终产品的质量.

关键词:
水性涂层是一种水性涂层.压缩 压缩是一种压缩.环境可持续性 环境可持续性微型计算机断层扫描 (micro-computed tomography) 是一种微型计算机断层扫描.

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科学领域:

  • 制药科学 制药科学
  • 材料科学 材料科学 材料科学

背景情况:

  • 水性平板电脑涂层是对有机溶剂涂层的环保替代品.
  • 基于水的涂料可能会引发质量问题,例如由于成分与水的相互作用而增加的孔隙性和裂纹.

研究的目的:

  • 研究药物辅助剂混合物在压缩和水性涂层过程中的结构性行为.
  • 评估平板电脑组件机械性能对涂层后结构完整性的影响.

主要方法:

  • 四级混合物的压缩 (模型药物和三个辅助剂).
  • 用高糖水溶液涂层和肠道涂层.
  • 在每个阶段使用X射线微型计算机断层扫描 (XμCT) 测量孔径.

主要成果:

  • 在涂层后,XμCT揭示了一些药片的显著结构变化.
  • 在某些配方中,透度增加了高达12%.
  • 显示出显著塑料密度的平板电脑组件显示出更大的结构变化,包括胀和裂.

结论:

  • 平板电脑组件的机械性能对于确定水性涂层期间的结构变化至关重要.
  • XμCT是检测可能影响药片质量的形态变化的重要工具.
  • 需要仔细选择辅助剂,以减轻水性平板电脑涂层的质量问题.