类固醇激素,维生素D和黑激素在快速旋转的班次中,女性医院工作人员
Silvia Fustinoni1, Rosa Mercadante2, Elisa Polledri2
1Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy; Toxicology lab, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Toxicology letters
|November 30, 2024
概括
女医院护士的夜班工作破坏了荷尔蒙水平,增加了与压力相关的荷尔蒙,如皮质和降低维生素D. 然而,唾液中黑激素,皮质醇和皮质醇的昼夜节律仍然不受影响.
科学领域:
- 内分泌学 在内分泌学.
- 职业健康 职业健康 职业健康
- 时间生物学 时间生物学
背景情况:
- 夜班工作扰乱昼夜节律,与癌症等健康问题有关.
- 医疗人员经常在夜班工作,因此需要了解其对健康的影响.
- 轮班工作对女性医护人员荷尔蒙平衡的影响需要进行调查.
研究的目的:
- 评估夜班工作对女性医院雇员血清和唾液中类固醇激素,维生素D和黑激素水平的影响.
- 为了研究一个快速旋转的顺时针转班时间表如何影响特定的激素度.
- 为了确定口服避孕药的使用是否会改变轮班工作和激素水平之间的关系.
主要方法:
- 研究了97名女性医院工作人员 (46名轮班护士,51名白天工人).
- 在早晨的样本中测量了13种类固醇激素和维生素D的血清水平.
- 唾液皮质醇,皮质素和黑激素在早上和晚上样本中进行了评估,并对混因素进行了统计调整.
主要成果:
- 快速旋转的轮班工作与较高的血清皮质,11-脱氧皮质醇,脱水氨 (DHEA) 和androstenedione相关.
- 轮班工作与血清雌激素和维生素D水平的降低有关.
- 轮班工作并没有改变唾液中的黑激素,皮质醇和皮质醇的昼夜模式,口服避孕药调节了一些血清激素协会.
结论:
- 女护士的顺时针快速旋转轮班工作会提高某些荷尔蒙水平,这可能表明压力增加.
- 雌激素水平没有增加,尽管轮班工作,唾液激素节律仍然保持不变.
- 轮班工作对女性医疗保健工作者的荷尔蒙影响是复杂的,需要进一步研究,特别是关于压力标志物的研究.
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