臭虫源的恶性瘤之间的生存率和预后的差异
Quentin Hennocq1, William Pouillot1, Chloé Bertolus2
1Sorbonne Université, Paris, France; Department of Maxillo-Facial Surgery, Hôpital Pitié-Salpêtrière, Assistance Publique des Hôpitaux de Paris, Paris, France.
Journal of stomatology, oral and maxillofacial surgery
|November 30, 2024
概括
转移性乳腺母细胞瘤 (METAM) 和恶性口腔瘤 (MOT) 的存活率相似. 手术治疗有利于MOT患者,但在METAM或骨髓质纤维瘤 (AFS) 组中没有因素影响生存.
科学领域:
- 口腔和牙面部外科手术
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 转移性乳腺母细胞瘤 (METAM) 和恶性牙瘤 (MOT) 的预后尚不清楚.
- 现在METAM被归类为良性瘤,但其临床含义需要进一步研究.
- 牙发育瘤代表了一个多样化的群体,具有不同的恶性潜力.
研究的目的:
- 为了确定METAM和MOT的预后.
- 确定影响这些罕见瘤患者生存的因素.
- 为了比较不同组织学亚型的瘤的生存结果.
主要方法:
- 利用SEER数据库来获取1975-2020年间的患者数据.
- 包括251名患者在三个组织学组:METAM,MOT和阿美洛布拉斯纤维肉瘤 (AFS).
- 使用单变量和多变量分析分析了疾病特异性生存率 (DSS).
主要成果:
- 在METAM (77.4%),MOT (84.0%) 和AFS (71.1%) 之间没有观察到5年DSS的显著差异.
- 在MOT组中,手术治疗是对DSS的显著保护因素 (HR=0.483,p=0.038).
- 通过单变量分析,在METAM和AFS组中没有变量显著影响DSS.
结论:
- 尽管重新分类,METAM带来了与MOT相当的重大生命风险.
- 在METAM,MOT和AFS中,生存结果类似.
- 手术干预对于改善MOT患者的生存率至关重要.
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