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丹古伊黄开通过抑制JAK2/STAT3介导的炎症来改善内皮功能障碍

Yuanying Xu¹, Wenjun Sha¹, Jun Lu¹

¹Department of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200333, China.

Journal of ethnopharmacology

|November 30, 2024

概括

唐贵黄 (DGLHD) 有效地改善了2型糖尿病患者的血管内皮功能. 它通过抑制JAK2 / STAT3通路,减少炎症和改善内皮健康而起作用.

科学领域:

药理学药理学是指药理学的学科.
生物医学工程生物医学工程
综合医学是一个整体医学.

背景情况:

血管内皮功能障碍 (VED) 是糖尿病血管并发症的主要驱动因素.
丹圭黄开 (DGLHD) 在治疗这些并发症方面表现有前途,但其在2型糖尿病相关血管内皮功能障碍 (T2DM-VED) 中的临床作用和机制需要进一步调查.

研究的目的:

临床验证DGLHD在T2DM-VED中改善内皮功能方面的疗效.
阐明DGLHD减轻T2DM-VED的药理动力学和分子机制.

主要方法:

使用ELISA和流媒扩张 (FMD) 对DGLHD对血管内皮功能影响的临床评估.
对DGLHD组件的UHPLC-Q-Exactive轨道飞行分析.
网络药理学和分子对接以预测治疗点.
在体外 (HUVEC) 和体内 (老鼠模型) 实验以验证机制,包括JAK2/STAT3通路的西部斑分析.

主要成果:

DGLHD含有201个活性成分,并调节JAK2/STAT3信号通路.
临床试验表明,DGLHD显著降低了促炎因素,并在T2DM患者中改善了口炎.
DGLHD抑制了JAK2/STAT3酸化,减少了炎症和血管内皮生长因子的释放,从而减轻了体外和体内炎症.

结论:

DGLHD在提高T2DM患者的内皮功能方面具有显著的潜力,这些患者患有动脉样硬化心血管疾病 (ASCVD) 的高风险.
治疗效果归因于抑制JAK2 / STAT3信号通路,导致减少前炎性和血管内皮生长因子的释放和VED的缓解.

关键词:

丹古伊柳花 (Danggui liuhuang) 制剂 - - 一种制剂.通过JAK2/STAT3路径.网络药理学网络药理学 2型糖尿病是什么? 2型糖尿病是什么血管内皮功能障碍血管内皮功能障碍

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