代谢状态调节超重和肥胖成年人的全球和地方大脑年龄估计
Shalaila S Haas1, Fahim Abbasi2, Kathleen Watson2
1Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.
Biological psychiatry. Cognitive neuroscience and neuroimaging
|November 30, 2024
概括
代谢健康不佳加快了大脑的衰老,特别是在许多胰岛素受体的区域. 维持新陈代谢健康对于保持大脑功能和延长健康寿命至关重要.
科学领域:
- 神经科学是一个神经科学.
- 代谢健康 代谢健康
- 衰老研究研究 衰老研究
背景情况:
- 保持大脑健康对于长寿和独立至关重要.
- 大脑退化和认知能力下降是导致残疾的重要原因.
- 研究了代谢健康对大脑衰老的影响,特别是大脑年龄差距估计 (brainAGE).
研究的目的:
- 检查代谢健康状况与大脑年龄差距估计 (brainAGE) 之间的关系.
- 为了确定受代谢健康状况影响的特定大脑区域.
主要方法:
- 114名健康成年人接受了代谢标志物评估和T1权重的大脑MRI.
- K-意味着将被分类的参与者分为有利的和不理想的代谢健康群体.
- 计算了voxel水平和全球脑AGE;对53名参与者分析了超过3年的纵向数据.
主要成果:
- 确定了两个代谢组:有利的 (n=58) 和次优的 (n=56).
- 非最佳组表现出胰岛素耐药性和脂质失调症,具有显著的全球和本地大脑AGE.
- 在亚最佳组中,加速的大脑衰老在小脑,腹中前额和中间部区域最为明显.
结论:
- 低于最佳的代谢健康与加速的大脑衰老有关,特别是在富含胰岛素受体的区域.
- 代谢健康对于维持大脑功能和可能延长健康寿命至关重要.
相关概念视频
Aging
37
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
37
Obesity
379
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
379
Cognitive Development During Adulthood
55
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
55


