视觉皮层的负血液动力学反应:证据支持通过血液动力学观察和双光子成像支持神经元起源的证据
Zhen Li1, Lihua He1, Limin Peng1
1College of Intelligence Science and Technology, National University of Defense Technology, Changsha, China.
Brain research bulletin
|November 30, 2024
概括
神经成像显示,在刺激期间的负血液动力学反应 (NHR),通常是远距离观察到的,是由神经元失活驱动的. 这为大脑中的抑制机制提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 系统神经科学 系统神经科学
- 神经成像是一种神经成像.
背景情况:
- 在神经刺激过程中,负血液动力学反应 (NHR) 通常伴随着正血液动力学反应 (PHR).
- 对于NHR的潜在神经生理机制,特别是大脑远端区域的神经生理机制,人们还不太了解.
研究的目的:
- 为了研究NHR的特征和机制在远离主要刺激部位的大脑区域.
- 阐明神经元活动和脑血流变化在NHR中的作用.
主要方法:
- 在动物模型中利用了内在光学成像和双光子成像.
- 应用前肢电刺激,并分析了血液动力学和反应.
- 使用轴突追踪来绘制皮层-皮层突出.
主要成果:
- 前肢刺激诱导了主要体感皮质 (S1FL) 中强烈的PHR.
- 在初级视觉皮层 (V1) 观察到NHR信号,其特点是延迟发病和降低幅度.
- 在V1中,NHR与大脑血流减少和广泛的神经元反应抑制有关,尽管在细胞子集中存在轻微的神经元激活.
- 确定了从S1FL到V1的皮层-皮层突出.
结论:
- 神经元失活是远距离皮层区域NHR的重要贡献者.
- 这些发现提高了对NHR背后的抑制机制的理解.
- 表明S1FL和V1之间的功能联系有助于刺激引起的血液动力学变化.
相关概念视频
Vision
52.9K
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
52.9K
Visual System
523
Light enters the eye through the cornea, a transparent, dome-shaped surface covering the surface of the eyeball that helps to direct and focus incoming light. This light is then channeled toward the pupil, an adjustable opening whose size is controlled by the iris. The iris, a pigmented muscle, regulates the amount of light entering the eye by contracting or dilating the pupil, thereby ensuring optimal light levels for clear vision.
Once through the pupil, the light passes through the lens, a...
Once through the pupil, the light passes through the lens, a...
523
The Retina
67.7K
The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
67.7K
Anatomy of the Eyeball
6.0K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
6.0K
Color Vision
503
Color perception begins in the retina, the light-sensitive layer at the back of the eye. Two main theories explain how colors are seen: the trichromatic theory and the opponent-process theory. The trichromatic theory, proposed by Thomas Young in 1802 and extended by Hermann von Helmholtz in 1852, suggests that color vision is based on three types of cone receptors in the retina. These cones are sensitive to different but overlapping ranges of wavelengths corresponding to red, blue, and green.
503


