在中度至重度牛皮的患者中,secukinumab的长期持久性
Joaquín Borrás-Blasco1, Silvia Cornejo1, Alejandro Valcuende-Rosique2
1Servicio de Farmacia, Hospital de Sagunto, Valencia, Spain.
概括
在中度至重度的牛皮患者中,secukinumab表现出良好的持久性,超过70%的患者在一年后仍在接受治疗. 这项现实研究评估了其在成年患者中的有效性和安全性.
科学领域:
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
- 现实世界的证据研究研究.
背景情况:
- 中度至重度的牛皮需要有效的长期治疗选择.
- 塞库金努马布是一种用于治疗牛皮的生物疗法.
- 了解现实世界的结果对于治疗决策至关重要.
研究的目的:
- 评估secuquinumab的实际持续性,有效性和安全性.
- 为了评估secukinumab在中度至重度牛皮的成年患者的使用.
- 为了比较开始使用secukinumab的天真和非天真患者之间的结果.
主要方法:
- 使用两个医院的注册表和医疗记录进行的回顾性队列研究 (2015年2月至2024年3月).
- 包括患有中度至重度牛皮的成年患者,开始使用secukinumab.
- 通过药物占有率 (MPR ≥80%),有效性,安全性评估持续性,并使用Kaplan-Meier分析进行持续性估计.
主要成果:
- 分析了88名患有中度至重度牛皮的患者.
- 总体而言,secukinumab的持续时间为61.5个月;1年,2年和3年的持续率分别为72.7%,51.1%和39.8%.
- 停止治疗的原因包括缺乏疗效 (21.5%),部分反应 (9.2%) 和不良反应 (7.9%).
结论:
- 在治疗中度至重度牛皮的第一年内,secukinumab在超过70%的患者中表现出显著的持续性.
- 现实世界的数据支持sequukinumab在治疗牛皮方面的作用.
- 进一步的研究可以探索长期的有效性和安全性.
相关概念视频
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...
01:29Acute Kidney Injury III: Clinical Manifestations
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
01:25Clinical Significance of Antibiotic Resistance
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
01:12Chronic Inflammation: Introduction
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...