在第三下部手术中,ibuprofen L-arginine和dexamethasone的预防性或预防性同时使用:一种随机对照试验
Edson Luiz Cetira-Filho1, Paulo Goberlânio de Barros Silva2, Isabelle de Fátima Vieira Camelo Maia3
1Division of Oral and Maxillofacial Surgery, Postgraduate Program in Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil; Division of Oral and Maxillofacial Surgery, Christus University (UNICHRISTUS), Fortaleza, Ceará, Brazil.
Oral surgery, oral medicine, oral pathology and oral radiology
|November 30, 2024
概括
使用ibuprofen-arginine和dexamethasone组合的预防性止痛疗法有效地延迟了手术后的疼痛. 与单独使用任何一种药物相比,这种结合方法提供了优越的疼痛管理.
科学领域:
- 在口腔外科手术.
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- 下三手术通常会导致显著的术后疼痛和炎症.
- 有效的疼痛管理策略对于改善患者的治疗结果和生活质量至关重要.
- 预防性和预防性止痛旨在通过在手术前或手术后立即服用药物来减少术后疼痛.
研究的目的:
- 为了比较不同的先发性和预防性止痛策略在下三手术的疗效.
- 为了评估布洛芬-氨酸 (Ib-Ar) 和甲 (DX) 联合给药对疼痛,炎症和生活质量的影响.
- 评估对实验室参数,疼痛灾难化和睡眠质量的影响.
主要方法:
- 一个随机的,分口,三盲,受控的临床试验,涉及48名志愿者.
- 建立了四个组:G1 (Ib-Ar + DX),G2 (Ib-Ar +安慰剂-DX),G3 (安慰剂-Ib-Ar + DX) 和G4 (安慰剂-Ib-Ar +安慰剂-DX).这些组分别是G1 (Ib-Ar + DX) 和G2 (Ib-Ar +安慰剂-DX).
- 药物是在手术前1小时或手术后立即服用的.
主要成果:
- 与干预组 (4小时) 相比,安慰剂组的疼痛峰值较早发生 (2小时).
- 在安慰剂组中,胀的测量显著减少,但没有恢复到基线.
- 结合Ib-Ar和DX组 (G1) 显示了髓氧化酶 (MPO) 和甲 (MDA) 水平的显著降低.
结论:
- 联合预防性和预防性止痛与布洛芬-阿尔金因和德克萨米他有效延迟了下第三手术后的峰值疼痛.
- 与单独使用任何一种药物相比,两种药物的同时使用显示出更高的益处.
- 两组之间没有观察到水或三症的显著差异.
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