随着时间的推移,COVID-19 mRNA 疫苗接种后慢性疹的特征
Johan Schwab1, Mathilde Foglierini1,2, Eva Pescosolido3
1Division of Immunology and Allergy, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.
Communications medicine
|November 30, 2024
概括
在mRNACOVID-19疫苗接种后,特别是Spikevax助推疫苗接种后,慢性疹 (CU) 可能会出现. 这种情况与SARS-CoV-2感染或亚托皮直接无关,但可能在易受感染的个体中间接触发.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 在mRNA-1273 (Spikevax) COVID-19疫苗接种后,已经报告了新发慢性疹 (CU).
- 这项研究研究了疫苗接种后出现CU的患者的特征.
- 分析了SARS-CoV-2感染,亚托皮和抗疫苗IgE的作用.
研究的目的:
- 为了评估COVID-19 mRNA疫苗接种后患有慢性疹 (CU) 的患者.
- 确定SARS-CoV-2感染,亚托皮和IgE对CU开发中的疫苗的贡献.
- 在CU患者中评估后续mRNA疫苗剂量的安全性.
主要方法:
- 通过2022年和2023年的调查,对CU患者进行纵向监测.
- 在CU患者 (N=50) 和对照组 (N=135) 之间的血液检测结果的比较.
- 针对抗疫苗IgE,抗SARS-CoV-2幽默反应和亚托皮评估 (Phadiatop) 的基础细胞激活测试 (BAT).
主要成果:
- 接种疫苗后的CU发作发生在平均10天后,在中年女性中,在Spikevax增剂后更频繁.
- 在2023年,CU在53%的病例中持续存在;诱导性疹 (皮肤学) 是常见的.
- 最佳技术度的阳性与抗尖峰活性和年龄较小相关,但不特定于CU,抗核体阳性或亚托皮.
结论:
- 斯派克瓦克斯增强疫苗接种诱导抗疫苗IgE独立于CU.
- CU与COVID-19感染或亚托皮症没有直接关联.
- 四分之四的CU患者耐受了额外的mRNA疫苗剂量,这表明在易受影响的个体中间接触发.
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