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在生命早期,早产和满产婴儿之间的鼻子微生物群的比较

Olga Gorlanova^1,2, Annika Nissen-Kratzert^1,2, Nadja Mostacci³

¹University Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.

Pediatric research

|November 30, 2024

概括

过早出生婴儿的鼻子微生物群与满期婴儿不同,较大的兄弟姐妹会影响过早出生婴儿的微生物群组成. 过早影响了最初的细菌殖民,影响了Moraxella和Dolosigranulum等关键品种.

科学领域:

微生物学微生物学
新生儿健康新生儿健康
免疫学免疫学免疫学

背景情况:

呼吸道微生物群对于婴儿免疫发育至关重要.
对于影响早产婴儿出院后鼻子微生物群的因素的了解有限.
需要比较早产和早产婴儿之间的鼻子微生物群.

研究的目的:

研究影响早产婴儿鼻腔微生物群的因素.
在早产婴儿和早产婴儿之间比较鼻子微生物群组成.
确定两个群体之间的细菌属的差异.

主要方法:

分析了136名早产婴儿和299名早产婴儿的鼻子抽样.
使用Illumina MiSeq.进行16S-rRNA基因测序.
统计分析包括多变量线性回归和PERMANOVA.

主要成果:

与满期婴儿相比,早产婴儿表现出明显的鼻腔微生物群.
年长的兄弟姐妹的存在与贝塔多样性增加以及早产婴儿中莫拉塞拉和海莫菲勒斯的丰富性有关.
过早出生的婴儿减少了Moraxella和Dolosigranulum属的丰富性.

结论:

过早生育影响了最初的鼻微生物群殖民.
年长的兄弟姐妹对早产婴儿的鼻子微生物群产生重大影响.
在早产和早产婴儿之间的鼻子微生物群差异为细菌殖民轨迹提供了洞察力.

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