血清homocysteine与勃起功能障碍之间的关联:系统性审查和元分析
Peng Cheng1, Hui-Min Li2, Ya-Jun Shen1
1Department of Urology, the Second Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, China.
International journal of impotence research
|November 30, 2024
概括
这次元分析发现,在勃起功能障碍 (ED) 的男性中,血清同型半氨酸 (Hcy) 水平较高. 这些升高的Hcy水平特别在老年人,超重个体和中度ED患者中发现,这表明Hcy和ED之间存在联系.
科学领域:
- 心血管健康 心血管健康
- 代谢综合征是代谢综合征的一种.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 勃起功能障碍 (ED) 是一种普遍的疾病,影响全球数百万人.
- 血清homocysteine (Hcy) 水平升高越来越多地被认为是心血管疾病的潜在危险因素.
- 需要进一步阐明ED和Hcy之间的关联.
研究的目的:
- 进行一项元分析,研究血清Hcy水平与ED之间的关系.
- 量化ED患者和对照组之间的Hcy水平差异.
- 探索影响这种关联的潜在缓解因素.
主要方法:
- 在主要数据库 (Web of Science,PubMed,Cochrane Library) 进行了系统的文献搜索,直到2023年7月.
- 分析包括12项研究,包括1766名ED患者和2340名对照.
- 使用STATA软件计算了标准化平均差异 (SMD) 和95%置信区间 (CI).
主要成果:
- 聚合分析显示,ED患者的血清Hcy水平与对照人群相比显著更高 (SMD = 0.97,p < 0.001).
- 亚组分析表明,40岁以上的ED患者,超重患者和具有轻度至中度国际勃起功能指数 (IIEF) 评分的患者的Hcy升高较大.
- 在来自地中海国家的ED患者中也观察到更高的Hcy水平.
结论:
- 这一元分析表明,血清Hcy水平升高与勃起功能障碍之间存在显著的关联.
- 年龄,超重状况和ED严重程度等因素可能会影响这种关系.
- 需要进一步的大规模,严格的研究来证实这些发现,并解决潜在的出版偏见.
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