与年龄相关的子宫变化及其与不良生殖结果的关联:系统性审查和元分析
Diana Marti-Garcia1, Asunta Martinez-Martinez1, Francisco Jose Sanz1
1IVI-RMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Av. Fernando Abril Martorell 106, Torre A, Planta 1ª, Valencia, 46026, Spain.
Reproductive biology and endocrinology : RB&E
|November 30, 2024
概括
35岁以后,由于子宫内膜老化,女性生育能力下降,影响怀孕成功. 本综述强调了不孕症的子宫内膜因子,并提出了改善生殖结果的抗衰老策略.
科学领域:
- 生殖医学 生殖医学
- 妇科 妇科 妇科 妇科
- 老年学是一门学科.
背景情况:
- 由于卵巢活动减少,女性生育能力在35-40岁之间显著下降.
- 有能力的子宫内膜对于成功怀孕至关重要,但子宫内膜衰老的影响被低估了.
- 较晚的孕产妇年龄对自然受孕和辅助生殖技术提出了挑战.
研究的目的:
- 系统地审查关于子宫内膜衰老对生殖结果的影响的文献.
- 分析母亲年龄对子宫内膜特征和怀孕成功率的影响.
- 为临床医生和研究人员提供关于子宫内膜老化在不孕症中的最新摘要.
主要方法:
- 在PubMed的系统文献搜索中寻找全文文章,直到2023年3月.
- 包括专注于子宫内膜,子宫,年龄和怀孕的研究,不包括生殖系统病理.
- 进行了对子宫内膜厚度,怀孕,植入,活产和流产率的元分析.
主要成果:
- 先进的孕产妇年龄 (35-40岁以上) 与子宫内膜较薄 (0.52毫米减少) 有关.
- 较年长的母亲年龄与较低的植入率 (27%) 和临床怀孕率 (20%) 相相关.
- 增加的流产率 (44%) 与晚年母亲的年龄有关.
结论:
- 子宫内膜衰老显著影响35-40岁以上女性的生殖结果.
- 考虑子宫内膜作为抗衰老策略的目标对于管理老年妇女不孕症至关重要.
- 鼓励进一步研究针对子宫内膜因子在不孕症中的定制抗衰老和预防策略.
相关概念视频
Oogenesis
63.4K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.4K
Menopause
138
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
138
Disorders of the Female Reproductive System
328
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
328
Infertility in Females
280
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
280
Meiosis vs. Mitosis
52.9K
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
52.9K
Hormonal Regulation of the Menstrual Cycle
296
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
296


