精神分裂症患者在声语音识别中的缺陷及其与精神病症状的关联
Shenglin She1, Bingyan Gong2, Qiuhong Li3
1Department of Psychiatry, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510145, China.
BMC psychiatry
|November 30, 2024
概括
精神分裂症患者表现出语音识别功能受损,特别是负面情绪表现. 这些缺陷与大脑灰质量和精神症状有关,表明潜在的治疗点.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 语音科学 语言科学
背景情况:
- 语音感知和情绪障碍与精神病症状有关.
- 伪音对精神分裂症 (SCHs) 语音识别 (SR) 的影响及其与精神症状的关系尚不清楚.
研究的目的:
- 为了研究SCHs中prosodicSR缺陷的神经支柱.
- 为了探索prosodicSR,大脑灰质体积 (GMV) 和SCHs中的精神症状之间的关联.
主要方法:
- 54名SCH和59名健康对照 (HC) 执行了一项SR任务,涉及中立,快乐,悲伤,愤怒,恐惧和厌恶的句子.
- 参与者接受了阳性和阴性综合征尺度 (PANSS) 评估和磁共振成像 (MRI) 扫描.
- 分析了prosodicSR,GMV和精神症状之间的关联.
主要成果:
- 负面的情绪表现 (悲伤,愤怒,恐惧,厌恶) 在两组中都损害了SR.
- 对于中性和快乐prosody条件,SR是相似的.
- 与愤怒和厌恶相比,SCH和HC在悲伤和恐惧的条件下表现出更好的SR.
- 快乐的SR与PANSS总,负和一般分数相关.
- 一个GMV成分 (47个地区) 与prosodic SR缺陷有关.
结论:
- 负面的情感假象阻碍了语音识别.
- 在SCH中,prosodic SR异常与传感运动,言语和情感处理区域的GMV减少有关.
- 研究结果表明,改善快乐的SR可能有助于通过神经可塑性缓解SCH的负面症状.
相关概念视频
Negative and Cognitive Symptoms of Schizophrenia
44
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
44
Positive Symptoms of Schizophrenia: Hallucinations and Delusions
63
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
63
Schizophrenia
70
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
70
Psychological and Sociocultural Causes of Schizophrenia
78
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
78
Positive Symptoms Schizophrenia: Hallucinations and Delusions
50
Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...
Hallucinations
Hallucinations in...
50
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
460
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
460


