三甘油糖指数与肥胖指标相结合,与认知障碍相关联
Juan Hao1, Yuting Lu2, Lei Zhang3
1Department of Neurology, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China.
TyG指数和腰围 (WC) 显示出与认知障碍的U形关系,特别是在非糖尿病和较低BMI的个体中. 代谢健康管理是预防认知衰退的关键.
科学领域:
- 老年学是指老年学的学科.
- 代谢健康 代谢健康
- 认知科学 认知科学
背景情况:
- 三甘-葡萄糖 (TyG) 指数和肥胖指标 (如腰围) 对认知功能的综合影响仍然在很大程度上未被探索.
- 本研究探讨了TyG-WC测量与认知障碍之间的未知关联,特别是在低收入的中国人群中.
研究的目的:
- 调查TyG-WC测量与老年人认知障碍之间的关系.
- 评估糖尿病和身体质量指数 (BMI) 在这种协会中的调节作用.
主要方法:
- 分析了1125名60岁及以上的个人.
- 计算和分类TyG指数和肥胖指标 (BMI,WC,腰与身高的比率).
- 多变量逻辑回归和受约束立方线分析探索了与认知障碍和MMSE分数的相关性和非线性关系.
主要成果:
- 认知障碍的患病率为47.3%. 在TyG-WC值和认知障碍 (P=0.008) 之间发现了显著的反向U形关联.
- 反向关联在非糖尿病患者和BMI较低的人 (<24 kg/m2) 中更为强烈.
- TyG-WC值与MMSE得分呈正相关,特别是在男性和非糖尿病患者中.
结论:
- 在TyG-WC值和认知功能之间存在非线性U形关系.
- 非糖尿病和低BMI个体可能从针对TyG-WC的干预措施中获益最多.
- 研究结果强调了代谢健康管理对于预防弱势群体认知能力下降的重要性.
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