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靠近红外光激活的纳米系统为脚手架提供可控的氧化释放,用于外围神经再生

Fangwei Qi¹, Wei Liu¹, Yanyan Chen²

¹Jiangxi Provincial Key Laboratory of Additive Manufacturing of Implantable Medical Device, Jiangxi University of Science and Technology, Nanchang 330013, China.

Journal of colloid and interface science

|December 1, 2024

概括

这项研究介绍了一种近红外触发的新型纳米系统,用于控制氧化 (NO) 释放,增强周围神经再生. 该系统提供持续的NO输送,以改善治疗结果.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
再生医学是一种再生医学.

背景情况:

在暴露在光线下,S-氨基 (CysNO) 释放氧化 (NO),显示神经再生的前景.
限制包括快速NO释放和需要低透紫外线的需要.

研究的目的:

开发近红外 (NIR) 触发的NO释放纳米系统,以增强外围神经再生.
克服与CysNO相关的突发释放和浅层组织透的局限性.

主要方法:

制造一个UCNP@ZIF-8/CysNO纳米系统,使用装载CysNO的上转化纳米颗粒 (UCNP) 和地质化伊米达酸框架-8 (ZIF-8) .
纳米系统通过激光增材制造将纳米系统纳入聚乳酸支架.
使用Griess方法评估NO释放动力学和NIR光的可控性.
评估神经元差异化使用免疫光染色对Nestin和GFAP.

主要成果:

在NIR照射下,UCNP@ZIF-8/CysNO纳米系统证明了持续和稳定的NO释放.
红外线光触发了UCNP的紫外线辐射,激活了CysNO以产生深层组织透的NO.
释放NO上调的神经标记物Nestin和GFAP,表明干细胞分化成神经元,可能是通过增强的Ca2+流入.

结论:

开发的NIR触发的NO释放支架为外围神经修复提供了一个有前途的策略.
通过深透的NIR光控制的NO输送克服了以前的限制.
这种方法为推进神经再生疗法提供了一个新的视角.

关键词:

有控制释放的释放.氧化氧化是什么?修复外围神经的修复向上转换纳米粒子泽奥利特性意达酸框架-8-8

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Nitric Oxide Signaling Pathway

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Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...