在精神分裂症和双相情感障碍中补充通路基因表达的分离变化:在亚垂体区域的炎症和神经发生的联系
Rachel E H Sager1, Hayley F North2, Christin Weissleder3
1Department of Neuroscience & Physiology, Upstate Medical University, Syracuse, NY 13210, USA.
Schizophrenia research
|December 1, 2024
概括
在精神分裂症和双相情感障碍中,大脑子依赖区 (SEZ) 的补充因子发生变化,影响神经发生. 这些变化表明在这些精神疾病中存在不同的分子路径.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 精神病学是一个精神病学.
背景情况:
- 亚依赖性区域 (SEZ) 神经发生缺陷与精神分裂症和双相情感障碍的炎症有关.
- 补充因子在SEZ中的作用及其对这些疾病中神经发生的影响尚不清楚.
研究的目的:
- 在精神分裂症和双相情感障碍患者的SEZ中研究补充因子mRNA表达的变化.
- 探索SEZ中补充因子表达,炎症水平和神经发生标志物之间的关系.
主要方法:
- 从93个大脑的SEZ中提取RNA (32个对照组,32个精神分裂症,29个双相情感障碍病例).
- 使用定量RT-PCR测量13个补剂相关转录的丰度.
- 基于诊断和炎症子组 (高或低炎症) 进行了分析.
主要成果:
- 在高度炎症的精神分裂症中,补充mRNAsC1QA,C1QB,C1R和B因子与低炎症对照相比增加.
- 高炎症双极性障碍病例显示C1QC和C3mRNA水平下降.
- 补充mRNAsC1R,C1S和B因子在低炎症精神分裂症和双相情感障碍小组和对照组中下降.
- 补充抑制剂H因子和CD59在高度炎症的子组显示出改变的表达.
- 补充因子与神经干细胞标记物正相关,与未成熟神经元标记物负相关.
结论:
- 改变的补体级联表达发生在精神分裂症和双相情感障碍的SEZ中,在高和低炎症状态中具有不同的模式.
- 在这些精神疾病中,补充激活可能会影响神经干细胞静止和新生神经元的分化或生存.
相关概念视频
Biological Causes of Schizophrenia
46
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
46
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
460
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
460
Human Genetics
535
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
535
Bipolar Disorder
56
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
56


