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猪表达促进了口腔致癌的进展

Daniel Peña-Oyarzún¹, Andrew F G Quest², Lorena Lobos-González²

¹School of Odontology, Faculty of Odontology and Rehabilitation Sciences, Universidad San Sebastián, Santiago, Chile.

Neoplasia (New York, N.Y.)

|December 1, 2024

概括

猪 (PORCN) 在口腔状细胞癌 (OSCC) 中被上调,其抑制减少了口腔病变的发展. 这凸显了PORCN作为口腔癌预防和治疗的潜在治疗标.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
致癌的发生是致癌的产生.

背景情况:

口腔状细胞癌 (OSCC) 通常是由癌前张力症引起的.
Wnt/β-catenin通路与OSCC的发展有关,促进细胞存活和增殖.
(PORCN) 对于Wnt配体分泌至关重要,其在OSCC中的作用目前尚不清楚.

研究的目的:

为了研究猪 (PORCN) 在口腔状细胞癌 (OSCC) 癌症发生中的作用.
在OSCC模型中评估新型PORCN抑制剂LGK974的治疗潜力.

主要方法:

使用了ex vivo,in vivo和in vitro的OSCC致癌模型.
在发育不良和OSCC组织中评估PORCN表达.
向暴露于4-尼托基诺林-1-氧化物 (4NQO) 的小鼠施用LGK974,这是一种致癌替代物.

主要成果:

在高度发育不良和差异化OSCC中,PORCN表达显著增加.
在OSCC中,关键Wnt/β-catenin通路蛋白也被提升.
在小鼠模型中,LGK974治疗减少了口腔病变的数量和大小.

结论:

葡萄糖在口腔状细胞癌的致癌过程中起着重要作用.
使用LGK974抑制PORCN表明对口腔病变有治疗作用.
在OSCC中,PORCN代表了一个有前途的治疗点.

关键词:

口腔致癌的发生.口腔状细胞癌的癌症.葡萄猪是什么意思葡萄猪是什么意思在Wnt/β-catenin信号通路中.

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