尾切除术,急性尾炎和胃肠道疾病:孟德尔的随机化研究
Yi Zhao1, Xuecheng Bai1, Yi Ding1
1Department of General Surgery (Hepatopancreatobiliary Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, People's Republic of China; Academician (Expert) Workstation of Sichuan Province, Metabolic Hepatobiliary and Pancreatic Diseases Key Laboratory of Luzhou City, The Affiliated Hospital of Southwest Medical University, Luzhou, People's Republic of China.
American journal of surgery
|December 1, 2024
概括
尾切除术和急性尾炎会影响胃肠道疾病的风险. 尾切除术与结肠癌和原发性硬化性胆管炎有关,而尾炎增加了胆结石的风险.
科学领域:
- 胃肠病学和遗传学研究.
- 研究尾炎和尾切除术对健康的长期影响.
背景情况:
- 尾切除术是急性尾炎的标准治疗方法.
- 尾切除术和急性尾炎对胃肠道疾病的长期影响尚不清楚.
研究的目的:
- 研究尾切除术和急性尾炎对各种胃肠道疾病风险的独立影响.
- 使用门德尔的随机化来分析遗传关联.
主要方法:
- 对尾切除术和急性尾炎的全基因组显著遗传变异被确定为仪器变量.
- 进行了两个样本的门德尔随机化 (MR) 分析.
- 单变量和多变量MR模型检查了独立的影响.
主要成果:
- 尾切除术与结肠癌的风险增加有关 (OR,1.54) 和原发性硬化性胆道炎 (OR,0.57) 的风险降低.
- 急性尾炎与胆病 (胆结石) 的风险更高有关 (OR, 1.16).
- 在FDR校正后,结果显著.
结论:
- 尾切除和急性尾炎可能会影响特定胃肠道疾病的风险.
- 研究结果表明,在欧洲人群中,尾状况/手术和随后的胃肠道健康结果之间存在潜在的联系.
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