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暴露于中国的甲酸盐和心血管疾病:基于社区的横截面研究和基准剂量估计

Lei King¹, Lili Xia¹, Juan Chen¹

¹Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Environmental pollution (Barking, Essex : 1987)

|December 1, 2024

概括

在中国,高化物暴露与心血管疾病 (CVD) 风险增加有关. 这项研究确定了甲酸盐的较低起点,表明需要更严格的法规来保护公共心血管健康.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
心血管疾病流行病学

背景情况:

众所周知,甲酸盐暴露会抑制甲状腺吸收,但其与中国心血管疾病 (CVD) 的关联尚不清楚.
目前,基于中国人群中观察到的不良健康影响,没有针对酸盐的具体出发点 (POD).

研究的目的:

调查中国成年人暴露在甲酸盐和心血管疾病 (CVD) 之间的关联.
为了确定介导酸盐和心血管疾病之间的关系的心脏代谢风险因素.
通过贝叶斯基基准剂量 (BMD) 建模,推导出百酸盐的特定人群起点 (POD).

主要方法:

一项对中国深2355名成年人进行的横截面研究,测量尿酸度以估计每日摄入量.
使用多变量逻辑回归来评估甲酸盐暴露与心血管疾病流行之间的关联.
调解分析检查了肥胖,高血压,糖尿病和高脂血症的作用.
用贝叶斯基准剂量 (BMD) 建模来确定甲酸盐的POD.

主要成果:

暴露于甲酸盐的最高三位数中的个体显示,患有常见心血管疾病的风险显著增加 (OR: 2.16).
甲酸盐暴露与每倍增加的高血压 (OR: 1.11),糖尿病 (OR: 1.15) 和高脂血症 (OR: 1.11) 的几率增加有关.
高血压,糖尿病和高脂血症部分介导过酸盐和心血管疾病之间的关联,占7.75%至11.30%.

结论:

甲酸盐暴露与中国成年人心血管疾病 (CVD) 的风险增加有关,部分由心脏代谢风险因素介导.
甲酸盐暴露的推导出发点 (POD) 低于此前推的值.
研究结果表明,需要对酸盐污染进行更严格的监管,以保护中国的心血管健康.

关键词:

基准剂量的基准剂量心血管疾病是什么心血管疾病横截面研究横截面研究甲甲酸是什么甲甲酸是什么甲甲是什么

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