欧米茄3和心房的风险:阴道介导的双刃剑
Evan L O'Keefe1, James H O'Keefe1, Hussam Abuissa2
1Saint Luke's Mid America Heart Institute and University of Missouri-Kansas City, Kansas City, MO, United States of America.
Progress in cardiovascular diseases
|December 1, 2024
概括
饮食中摄入较高的omega-3脂肪酸,包括eicosapentaenoic acid (EPA) 和docosahexaenoic acid (DHA),与心房的风险降低有关. 然而,药物剂量的欧米茄-3脂肪酸会增加AF风险,可能是由于管度的影响.
科学领域:
- 心血管研究研究心血管研究
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 关于omega-3脂肪酸 (eicosapentaenoic acid [EPA]和docosahexaenoic acid [DHA]) 和心房动 (AF) 风险,存在相互矛盾的结果.
- 了解剂量依赖的效应和潜在的媒介对于临床实践至关重要.
研究的目的:
- 澄清海洋欧米茄-3摄入量对发展心房动 (AF) 的风险的影响.
- 探索阴道声调作为欧米茄-3和AF风险之间的关系中的潜在调解者的作用.
主要方法:
- 随机临床试验 (RCT),流行病学研究和元分析的系统审查.
- 使用PubMed的文献搜索,使用关键词:心房动,omega-3,EPA,DHA和阴道音调.
- 对剂量-反应关系的分析和管声调的影响的探索.
主要成果:
- 对RCT的元分析 (8项研究,83,112名参与者) 显示,随着DHA/EPA治疗,AF风险增加了24% (4.0%与3.3%相比),取决于剂量.
- 较高的药物剂量 (1800-4000毫克/天) 显著增加了AF风险 (约. 50%),而较低的剂量 (大约. 1000 mg/d) 显示出较小的增加 (约. 只有12%的人 (12%).
- 观察性研究 (17项研究,54,799名参与者) 表明,较高的饮食摄入量或血液中DHA/EPA水平与AF风险降低有关 (在~650mg/d时最大降低12%).
- 欧米茄-3脂肪酸可以剂量取决于增加阴道度,这可能解释了DHA+EPA和AF风险之间观察到的双相关系.
结论:
- 饮食中摄入欧米茄-3脂肪酸与心房的风险降低有关.
- 欧米茄-3脂肪酸的药物管理增加AF风险以剂量依赖的方式.
- 阴道调节可能会调解omega-3s和AF风险之间的观察到的关系.
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