异性食道炎驱动组织纤维细胞再生计划向病理性功能障碍
Medet Jumabay1, Edsel M Abud2, Kevin Okamoto1
1Department of Pediatrics, University of California, San Diego, Calif; Division of Allergy Immunology, University of California, San Diego, Calif.
The Journal of allergy and clinical immunology
|December 1, 2024
概括
在性食道炎 (EoE) 中的慢性炎症会产生致病性纤维细胞,阻碍组织修复. 向腺三酸盐处理和CD73可能会恢复纤维细胞功能,并改善2型炎症疾病的愈合.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 病理组织重塑,痕和硬是炎症性,自身免疫性和过敏性疾病的标志.
- 性食道炎 (EoE) 涉及组织重塑,导致食道障碍和食道狭窄,但潜在的分子机制尚不清楚.
- 纤维细胞功能障碍与EoE相关的组织重塑有关.
研究的目的:
- 为了调查慢性EoE炎症诱导具有受损组织再生和运动性的致病性纤维细胞的假设.
- 为了阐明驱动纤维细胞功能障碍的分子机制,EoE.
主要方法:
- 单细胞RNA测序以分析EoE和健康纤维细胞的转录特征.
- 光激活细胞分类 (FACS) 和功能测试,以评估纤维细胞分化,迁移和CD73活性.
- 在体内和体外实验中诱导和拯救EoE纤维细胞功能障碍.
主要成果:
- EoE纤维细胞表现出亲炎性和亲刚性转录程序,保留了类似于冠状细胞的分化,但失去了类似于脂肪细胞的能力.
- EoE纤维细胞显示迁移增加和CD73表达和活性降低,表明异常的细胞外腺三酸盐处理.
- 在健康的纤维细胞中,EoE纤维细胞功能障碍可以通过降低CD73活性来重现,并通过腺重复逆转.
结论:
- 慢性EoE炎症驱动病原性纤维细胞表型,其特点是改变了组织再生和运动性.
- 干扰细胞外腺三酸盐处理和CD73活性是EoE纤维细胞功能障碍的关键机制.
- 调节腺三酸盐处理和CD73为改善EOE和其他2型炎症疾病中的组织再生提供了潜在的治疗策略.
关键词:
这就是ATPATPATP ATP.CD73 CD73 CD73 CD73 CD73 CD73 CD73 CD73 CD73 CD73 CD73埃索诺菲尔性食道炎是什么?氨酸 (Adenosine) 是一种氨酸.纤维化 纤维化改造 改造 改造 改造 改造 改造更多相关视频
10:15Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
Published on: March 22, 2017
6.9K
11:58Functional Characterization and Visualization of Esophageal Fibroblasts Using Organoid Co-Cultures
Published on: January 6, 2023
2.5K
相关概念视频
01:22Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.2K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K
01:21Barrett Esophagus-I: Introduction
66
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
66
01:21Barrett Esophagus-II: Clinical Manifestations and Management
109
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
109
01:30Esophageal Strictures-I: Introduction
65
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
65
01:29Gastroesophageal Reflux Disease I: Meaning and Pathophysiology
289
Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
289
01:26Asthma-II: Pathophysiology and Classification
2.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K