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C1q/TNF相关蛋白-1与动脉样硬化之间的因果关系的遗传证据:双向和多变量门德尔随机化研究

Juhong Pan¹, Jia Huang¹, Yueying Chen¹

¹Department of Ultrasound Imaging, Renmin Hospital of Wuhan University.

Journal of atherosclerosis and thrombosis

|December 1, 2024

概括

与C1q/TNF相关的蛋白-1 (CTRP1) 因果影响大脑,冠状动脉和其他动脉动脉样硬化. 这表明CTRP1是系统性动脉样硬化预防和治疗的潜在治疗标.

科学领域:

心血管遗传学心血管遗传学
代谢性疾病研究研究
遗传流行病学遗传流行病学

背景情况:

与C1q/TNF相关的蛋白-1 (CTRP1) 与冠状动脉疾病有关.
了解CTRP1在各种血管部位的动脉样硬化中的作用至关重要.

研究的目的:

调查CTRP1和动脉样硬化之间的因果关系.
检查CTRP1在不同血管床的作用,包括大脑,冠状动脉和其他动脉.

主要方法:

利用孟德尔的随机化 (MR) 分析与全基因组关联研究和FinnGen生物库的总结统计数据.
进行了初级MR分析,灵敏度分析 (科克兰的Q,留出一个) 和质性评估 (MR-Egger,MR-PRESSO).
使用缺血性中风队列验证的发现,并使用多变量MR (MVMR) 来评估独立的影响.

主要成果:

证实了CTRP1对大脑 (OR=1.31),冠状动脉 (OR=1.13) 和其他动脉动脉样硬化 (OR=1.06) 的因果作用.
验证队列支持CTRP1在大动脉动脉样硬化中的因果作用 (OR=1.10).
反向MR分析排除了导致CTRP1变化的动脉样硬化;MVMR证实了CTRP1对动脉样硬化的独立作用.

结论:

CTRP1在系统性动脉样硬化中发挥了因果作用.
CTRP1成为预防和治疗动脉样硬化的潜在治疗标.

关键词:

动脉样硬化是一种动脉样硬化.与C1q/TNF相关的蛋白-1 冠状动脉疾病是一种冠状动脉疾病.缺血性中风是因为缺血性中风.门德尔的随机化多变量是多变量的.

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