威尚药丸通过调节脑肠和肠道微生物群来缓解功能性消化不良
Liao Mengting1, L I Tao2, Chu Fuhao2,3
1Department of Internal Medicine, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100010, China.
概括
伟张是一个伟大的城市.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 功能性消化不良 (FD) 是一种常见的胃肠道疾病.
- 目前对FD的治疗有局限性.
- 了解FD的机制对于开发有效疗法至关重要.
研究的目的:
- 在大鼠模型中评估微安药 (WCAP) 在治疗功能性消化不良 (FD) 的疗效.
- 研究WCAP对脑肠 (BGPs) 和肠道微生物群的影响.
- 阐明WCAP对FD的潜在治疗机制.
主要方法:
- 功能性消化不良的老鼠模型是使用特定的和压力协议建立的.
- 通过木炭推进试验评估了胃肠道运动性.
- 使用ELISA测量了motilin (MTL), gastrin (GAS),血管活性肠 (VIP) 和 somatostatin (SS) 的血清水平.
- 用16S rRNA测序分析了肠道微生物组成.
主要成果:
- 在老鼠中,WCAP治疗显著改善了FD症状,因为它加速了胃排空和小肠过境.
- WCAP调节了BGP水平,增加了GAS和MTL,同时减少了VIP和SS.
- WCAP治疗恢复了肠道微生物群的平衡,包括Firmicutes/Bacteroidetes比率和物种丰富度.
结论:
- 在功能性消化不良的老鼠中,维安药有效促进胃肠运动障碍的恢复.
- WCAP的治疗机制涉及对脑肠分泌和肠道微生物群组成的调节.
- 作为功能性消化不良的治疗方法,WCAP显示出前景.
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