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保释囊缓解自身免疫性甲状腺炎调节过氧体增殖器激活受体信号通路:一个多omics分析

Wang Qixin¹, X U Liting¹, W U Jiangpeng²

¹State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

|December 1, 2024

概括

保释囊 (BL) 通过调节PPAR信号通路并抑制脂肪酸代谢,减少了自免疫甲状腺炎 (AIT) 的老鼠的甲状腺炎症. 这表明BL BL.

科学领域:

免疫学和内分泌学.
药理学和分子生物学

背景情况:

自身免疫性甲状腺炎 (AIT) 的特征是慢性炎症和免疫系统对甲状腺的攻击.
目前对AIT的治疗旨在控制症状和免疫反应,但需要新的治疗策略.
保释囊 (BL) 是一种具有潜在免疫调节功能的传统中医药制剂.

研究的目的:

评估Bailing囊 (BL) 在治疗自身免疫性甲状腺炎 (AIT) 的疗效.
阐明BL抗AIT作用的潜在分子机制.

主要方法:

建立了一个AIT大鼠模型来评估BL对甲状腺功能和炎症标志物的影响.
测量了甲状腺激素 (FT3,FT4,TSH) 和抗体 (TGAb,TPOAb) 的血清水平.
分析了炎症性细胞因子 (IFN-γ,IL-4,IL-10,IL-12) 和甲状腺组织病理.
经过西班牙的验证的转录组和蛋白质组分析被用来探索BL的作用机制.

主要成果:

在AIT大鼠中,BL治疗显著降低了甲状腺自身抗体 (TGAb,TPOAb),并使TSH水平正常化.
BL抑制了促炎性细胞因子 (IFN-γ,IL-12) 和促进了抗炎性细胞因子 (IL-4,IL-10).
BL改善了甲状腺组织结构和减少了炎症,分子分析显示了PPAR信号通路和脂肪酸代谢的调节.

结论:

在AIT大鼠模型中,保释囊 (BL) 在降低甲状腺炎症方面表现出显著的有效性.
治疗机制涉及调节过氧体增殖器激活受体 (PPAR) 信号通路并抑制脂肪酸代谢.
BL显示出作为自身免疫性甲状腺炎的临床治疗剂的潜力.

关键词:

一个保释囊.皮带塞普斯 (cordyceps) 是一种肌肉的组成部分.脂肪酸脂肪酸是一种脂肪酸.过氧体增殖器激活受体的受体甲状腺炎,自身免疫性炎症

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