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组织卡德林17 (CDH17):使用数字图像分析对结肠直肠癌的重要预后决定因素

Lui Ng¹, Wing Shan Yu^2,3, Nilar Myat Aung^2,3

¹Department of Surgery, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.

Cancer reports (Hoboken, N.J.)

|December 1, 2024

概括

通过自动化系统量化的卡德林17 (CDH17) 表达在结直肠癌 (CRC) 中升高,并与晚期疾病有关. 高CDH17水平预测CRC患者的整体存活率和无复发存活率较差.

科学领域:

在瘤学瘤学.
生物标志物发现发现
数字病理学数字病理学

背景情况:

结肠直肠癌 (CRC) 是一个重大的全球健康挑战,死亡率高.
有效的预后生物标志物对于改善CRC患者管理和生活质量至关重要.

研究的目的:

评估卡德林17 (CDH17) 组织表达在结直肠癌 (CRC) 的预后意义.
使用标准化的自动化免疫组织化学 (IHC) 平台,为CDH17评估提供数字化评分.

主要方法:

在150个追溯的CRC瘤组织中评估CDH17表达,使用自动化IHC.
通过计算机辅助的膜 (M) 评分和数字图像分析量化CDH17表达.
与临床病理因素相关的CDH17M评分,总生存率 (OS) 和使用卡普兰-梅尔和考克斯回归分析的无复发生存率 (RFS).

主要成果:

瘤组织中的CDH17表达显著高于正常的邻近组织 (p=0.0011).
升高的CDH17M评分与晚期TNM分期 (p<0.0162) 和远程转移 (p=0.0026) 相相关.
高的CDH17M得分与较差的生存状况 (p=0.0118) 和RFS (p=0.0021) 有显著的关联.
CDH17 M 评分独立预测了不良的生理状况 (HR=2.296, p=0.0240) 和RFS (HR=2.489, p=0.0447).

结论:

通过自动化IHC和数字评分测量的CDH17表达量的增加与晚期结直肠癌分期有关.
CDH17作为一个有价值的独立预后标记,用于预测CRC患者的生存结果.

关键词:

自动化免疫组织化学.卡德林 17 个国家结肠直肠癌是什么意思预后预后预后

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