在没有痴呆症的老年人中,与前性缩相关的神经精神症状
Ioannis Liampas1, Vasileios Siokas1, Polyxeni Stamati1
1Department of Neurology, University Hospital of Larissa, School of Medicine, University of Thessaly, Larissa, Greece.
International journal of geriatric psychiatry
|December 1, 2024
概括
前性缩 (FTA) 与轻度认知障碍 (MCI) 的老年人中神经精神症状 (NPS) 的增加有关. 在没有认知障碍的个体中没有观察到这种关联,这表明FTA可能会在MCI中导致NPS发展或有助于NPS发展.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 精神病学是一个精神病学.
背景情况:
- 神经精神症状 (NPS) 在老年人中很常见.
- 前性缩 (FTA) 是一种与认知衰退相关的神经病理发现.
- 在没有痴呆症的个体中,FTA和NPS之间的关系需要进一步调查.
研究的目的:
- 在没有痴呆症的老年人中调查前性缩 (FTA) 和神经精神症状 (NPS) 之间的关联.
- 为了确定FTA是否增加了在认知正常 (CU) 和轻度认知障碍 (MCI) 个体中经历NPS的可能性.
主要方法:
- 利用了50岁及以上的NACC参与者的数据,并使用了现有的FTA数据.
- 分别分析了认知正常 (CU) 和轻度认知障碍 (MCI) 组.
- 采用二进制物流回归来评估FTA和11个NPS之间的关联,包括高兴,异常运动行为,食欲障碍,冷漠和失禁.
主要成果:
- 在MCI组中,FTA与更高的兴奋率,异常的运动行为,食欲障碍,冷漠和消抑制有关.
- 在具有FTA的认知不受损 (CU) 个体中,没有发现NPS几率的显著升高.
- 指出了FTA和特定的NPS之间的潜在关系,尽管CU分析可能不足.
结论:
- 前性缩 (FTA) 与在被诊断为轻度认知障碍 (MCI) 的老年人中出现某些神经精神症状 (NPS) 的可能性增加有关.
- 这种关联在认知不受损 (CU) 个体中并不明显,这表明FTA在NPS中的作用可能特定于早期认知衰退阶段.
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