慢性病中的心血管自主神经病变:对脏活检病例的研究
Hideaki Kuno1, Go Kanzaki2, Rina Oba1
1Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, Tokyo, 105-8461, Japan.
BMC nephrology
|December 1, 2024
概括
心血管自主神经病变 (CAN) 影响9.7%的非糖尿病慢性病 (CKD) 患者,这一比例是健康个体的四倍. 慢性病患者的CAN与晚期损伤有关,特别是间歇性纤维化/管状缩.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 神经学 神经学
背景情况:
- 心脏和功能通过自主神经系统相互联系.
- 心血管自主神经病变 (CAN) 是糖尿病病 (DKD) 的已知并发症.
- 在非糖尿病慢性病 (CKD) 中,CAN的机制尚不清楚.
研究的目的:
- 为了确定非糖尿病性慢性结核病患者中CAN的患病率.
- 在这个人群中调查与CAN相关的临床病理学特征.
主要方法:
- 一项对165名接受脏活检的非糖尿病慢性病患者的横截面研究.
- 用RR间隔变化系数 (CVRR) 来测量心率变化 (HRV).
- 根据年龄和性别相关的CVRR参考值来诊断CAN.
主要成果:
- 在研究的队列中,CAN的患病率为9.7%.
- CAN与功能障碍,脂质障碍和晚期间歇性纤维化/管状缩 (IF/TA) 有关.
- IF/TA独立与CVRR相关,这是CAN的一个标志物.
结论:
- 在非糖尿病性CKD患者中,CAN的患病率明显高于一般人群.
- 先进的IF/TA是与非糖尿病CKD中CAN相关的关键特征.
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