肠道微生物组与血液和内脏脂肪组织中的DNA甲基化模式之间的相互作用,在具有不同代谢特征的受试者中
José Ignacio Martínez-Montoro1,2,3,4, Gracia M Martín-Núñez2,4, Andrés González-Jiménez2
1Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, 29010, Málaga, Spain.
Journal of translational medicine
|December 1, 2024
概括
肠道微生物组和DNA甲基组在具有不同代谢健康的个体中显示出不同的模式和相关性. 这些相互作用可能在肥胖和2型糖尿病等代谢疾病中发挥作用.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 代谢学 代谢学 代谢学
- 微生物组研究 微生物组研究
背景情况:
- 肠道微生物组影响宿主表观遗传学,可能有助于代谢疾病病理生理学.
- 表观遗传修饰与代谢障碍的发展有关.
研究的目的:
- 为了研究肠道微生物组和DNA甲基组之间的相互作用.
- 分析不同代谢特征的人群中的这些相互作用,包括肥胖和2型糖尿病.
主要方法:
- 机器学习应用于多omics数据 (肠道微生物组,血液和内脏脂肪组织DNA甲基组).
- 分析包括64名参与者,按代谢状况分类:健康对照组,具有不同胰岛素敏感度的肥胖症和2型糖尿病.
主要成果:
- 通过代谢组 (肥胖,2型糖尿病,胰岛素抵抗) 确定了不同的omics模式.
- 在肠道微生物组组成 (例如,Odoribacteriaceae,Christensenllaceae) 和DNA甲基组 (血液和增值税) 之间观察到显著的相关性.
- 细菌属 (Sutterella,Collinsella,Eubacterium) 与代谢基因的表观遗传调节有关.
结论:
- 在具有不同代谢特征的个体中发现了明显的肠道微生物组-DNA甲基组相互作用.
- 这些发现表明肥胖和相关疾病的潜在作用,需要进一步调查.
关键词:
通过DNA甲基化.表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.我们的肠道微生物群.胰岛素耐药性 胰岛素耐药性是一种肥胖问题 肥胖问题2 型糖尿病 2 型糖尿病内脏脂肪组织的脂肪组织.更多相关视频
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