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专利卵孔 (PFO):历史,诊断和管理

Aurel Maloku¹, Ali Hamadanchi¹, Albrecht Günther²

¹Department of Internal Medicine I, Cardiology, Angiology, Intensive Medical Care, University Hospital Jena, 07747 Jena, Germany.

Reviews in cardiovascular medicine

|December 2, 2024

概括

专利卵孔 (PFO) 关闭建议选择中风患者. 设备关闭对预防中风充满希望,正在研究其他应用,如偏头痛.

科学领域:

心脏病学心脏病学
神经学神经学
医疗器械医疗器械

背景情况:

卵孔 (PFO) 是密码性中风的潜在危险因素.
目前的指导方针建议在16-60岁的特定高风险中风患者中关闭PFO.
关闭PFO是一种既定的干预性心脏病程序.

研究的目的:

审查专利关闭的有效性和程序性方面.
通过PFO关闭来评估通过PFO关闭来预防中风所需治疗人数 (NNT).
讨论目前关于在中风患者中关闭PFO的证据和考虑.

主要方法:

从关键临床试验 (关闭,尊重,减少) 的数据分析.
对干预性PFO关闭技术和设备的审查.
评估并发症风险和术后管理.

主要成果:

预防中风复发的NNT有所不同:在CLOOSE/RESPECT中为20-44 (5年),在REDUCE中为28 (2年) 和18 (10年).
干预PFO关闭在技术上是可行的,但需要精细的技术.
抗血小板治疗是关闭后的标准治疗.

结论:

关闭PFO是有效的减少中风复发在选定的患者.
该程序通常是安全的,但需要谨慎执行.
除了中风以外的情况,例如偏头痛,PFO关闭的证据需要进一步调查.

关键词:

在PFO上,PFO是PFO.与PFO相关的中风偏头痛偏头痛偏头痛偏头痛一次性中风中风中风中风中风

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